Clinical Feasibility of Synthetic MRI in Multiple Sclerosis: A Diagnostic and Volumetric Validation Study.

AJNR. American Journal of Neuroradiology
Tobias GranbergMaria Kristoffersen-Wiberg

Abstract

Quantitative MR imaging techniques are gaining interest as methods of reducing acquisition times while additionally providing robust measurements. This study aimed to implement a synthetic MR imaging method on a new scanner type and to compare its diagnostic accuracy and volumetry with conventional MR imaging in patients with MS and controls. Twenty patients with MS and 20 healthy controls were enrolled after ethics approval and written informed consent. Synthetic MR imaging was implemented on a Siemens 3T scanner. Comparable conventional and synthetic proton-density-, T1-, and T2-weighted, and FLAIR images were acquired. Diagnostic accuracy, lesion detection, and artifacts were assessed by blinded neuroradiologic evaluation, and contrast-to-noise ratios, by manual tracing. Volumetry was performed with synthetic MR imaging, FreeSurfer, FMRIB Software Library, and Statistical Parametric Mapping. Repeatability was quantified by using the coefficient of variance. Synthetic proton-density-, T1-, and T2-weighted images were of sufficient or good quality and were acquired in 7% less time than with conventional MR imaging. Synthetic FLAIR images were degraded by artifacts. Lesion counts and volumes were higher in synthetic MR imaging ...Continue Reading

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Citations

Jul 23, 2016·AJNR. American Journal of Neuroradiology·M I VargasB M Delatre
Jul 23, 2016·AJNR. American Journal of Neuroradiology·T Granberg
Dec 10, 2016·AJNR. American Journal of Neuroradiology·A HagiwaraS Aoki
Jun 24, 2017·Pediatric Radiology·So Mi LeeMoon Jung Hwang
Mar 3, 2018·AJNR. American Journal of Neuroradiology·M Drake-PérezM I Vargas
Aug 4, 2018·AJNR. American Journal of Neuroradiology·M I VargasS Boudabous
Dec 6, 2018·Topics in Magnetic Resonance Imaging : TMRI·Fabrício Guimarães GonçalvesGiulio Zuccoli
Oct 20, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kelly C McPhee, Alan H Wilman
Mar 10, 2018·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jisook YiJin-Suck Suh
Jul 2, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Michael G DwyerRobert Zivadinov
Feb 15, 2020·Annals of Neurology·Russell OuelletteTobias Granberg
May 27, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Gabriel MangeatTobias Granberg
May 22, 2018·Acta Radiologica Open·Sana BoudabbousMaria Isabel Vargas
Mar 19, 2019·Journal of Magnetic Resonance Imaging : JMRI·Kanghyun RyuDong-Hyun Kim
Jul 10, 2018·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Koung Mi KangChul-Ho Sohn
Dec 21, 2019·AJNR. American Journal of Neuroradiology·M I VargasT Meling
Nov 15, 2017·European Radiology·Wolfgang KraussPer Thunberg
Oct 20, 2020·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Tokunori KimuraKouta Fukatsu
Feb 5, 2021·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Tomoyuki FujiokaUkihide Tateishi

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