Clinical Feature and Outcome of Childhood Status Epilepticus in a Teaching Hospital, Odisha, India

Curēus
Kedarnath DasSaroj Satpathy

Abstract

Objectives The main aim is to find out the clinical feature and outcome of status epilepticus (SE) in children managed in a teaching hospital. The secondary aim is to identify the risk factors influencing the adverse outcomes. Methods In this prospective cohort, children aged 1 month to 14 years with SE as per the International League Against Epilepsy's new guideline (2016) who presented to the emergency department during the period of November 2017 to October 2019 were enrolled. Clinical profile, treatment, and outcome of cases (n = 94) were noted. Results The majority of children, 60 (63.82%), were less than five years of age. Prior history of seizures was present in 33 (35.1%) cases, whereas 61 (64.9%) cases presented with SE as the first episode of seizure. In 14 (42.4%) previous seizure cases, SE was due to drug default. No response to first-line antiepileptic drug (AED) was seen in 84 (89.37%) cases. Acute symptomatic etiology was the commonest etiology of SE in 64 (68%) cases, of which neuro-infections accounted for 44 (46.80%) cases. Longer duration (>60 minutes) of status (p < 0.01), ventilator support (p < 0.0001), and circulatory impairment (p < 0.0001) were attributable risk factors for mortality. A total of 28 chil...Continue Reading

References

Mar 11, 2005·Indian Journal of Pediatrics·Sheffali GulatiM R Sridhar
Jul 27, 2007·Epilepsia·Jagarlapudi M K MurthyMeena A Kanikannan
Feb 6, 2008·Lancet Neurology·Manish SadaranganiCharles R Newton
Sep 5, 2009·Journal of Neurology·J KalitaUsha Kant Misra
Mar 30, 2013·Critical Care Clinics·Ryan Wilkes, Robert C Tasker
Sep 2, 2014·Journal of Clinical and Diagnostic Research : JCDR·Mritunjay KumarNigam Prakash Narain
Feb 19, 2016·Seizure : the Journal of the British Epilepsy Association·Lokesh LingappaSita Jayalakshmi
Apr 19, 2016·Journal of Clinical Medicine·Douglas M SmithNicholas S Abend
Jan 23, 2018·JAMA Neurology·Marina Gaínza-LeinUNKNOWN Pediatric Status Epilepticus Research Group
Aug 28, 2018·Epilepsia·Claudine SculierTobias Loddenkemper
Aug 31, 2018·Epilepsia·Monica FerlisiUNKNOWN International Steering Committee of the StEp Audit
Mar 1, 2019·Journal of Global Infectious Diseases·Sandeep Kumar TripathyRashmi Ranjan Das

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Citations

Dec 15, 2020·Curēus·Abhilipsa AcharyaNiranjan Mohanty

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS

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