Clinical Features and Comorbidities of Patients With Necrobiosis Lipoidica With or Without Diabetes

JAMA Dermatology
David A HashemiMisha Rosenbach

Abstract

Necrobiosis lipoidica (NL) is a rare granulomatous condition. Current knowledge of its key features is based on a limited number of studies and case reports, leading to wide variability in the characterization of its defining features, with limited comparison of patients with or without diabetes. To evaluate the epidemiologic characteristics, clinical features, and disease associations of NL in patients with or without type 1 or 2 diabetes. This multicenter retrospective review included 236 patients aged 15 to 84 years who were evaluated and received a diagnosis of NL at the University of Pennsylvania Health System between January 1, 2008, and July 15, 2018; University of Iowa Hospitals and Clinics between January 1, 2000, and June 15, 2018; and Brigham and Women's Hospital and Massachusetts General Hospital between January 1, 2000, and February 15, 2018. Patient demographics, clinical features, medical comorbidities, and biopsy status. Of the 236 patients with NL, 200 were women and 36 were men, and 182 were white, with a median age at presentation of 50.0 years (interquartile range, 33.0-59.0 years). The diagnosis was biopsy proven in 156 patients (66.1%). Of the 230 patients with location specified, 225 (97.8%) had NL on the...Continue Reading

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Citations

Feb 15, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·C Erfurt-Berge, M Sticherling
Jan 4, 2021·Lasers in Medical Science·Rana AbdatF Clarissa Yang
Mar 17, 2021·Journal of the American Academy of Dermatology·Kevin J SeversonAaron R Mangold
Apr 21, 2021·Journal of the American Academy of Dermatology·Kevin J SeversonAaron R Mangold
Jul 20, 2021·JAAD Case Reports·Ashley DiLorenzoMichael A Cardis
Aug 20, 2021·The American Journal of Dermatopathology·James AbbottLauren Madigan
Aug 24, 2021·SAGE Open Medical Case Reports·Meghan L McPhieMelinda J Gooderham
Sep 16, 2021·Plastic and Reconstructive Surgery. Global Open·Gilles AbsilArjen F Nikkels
Apr 8, 2021·Dermatology : International Journal for Clinical and Investigative Dermatology·Cornelia Erfurt-BergeRegina Renner

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