PMID: 18409536Apr 16, 2008Paper

Clinical features and course of 5 cases with HIV encephalopathy

Rinshō shinkeigaku = Clinical neurology
Rina HashimotoMotohiro Hamaguchi

Abstract

Clinical features and courses of 5 cases with HIV encephalopathy were reported. The subjects were among the patients registered as HIV patients at the Nagoya Medical Center, between 1996 and 2005. There were 458 patients with HIV infection including 127 cases of AIDS. All patients suffered from severe immunological deficiency when HIV encephalopathy developed. Other opportunistic infections had also occurred in three patients. HIV encephalopathy was one of the presenting manifestations of HIV infection in four patients, and no patients had received antiretroviral therapy. HAART improved motor disturbance and their ADL became independent except for one case. Improvements in neuropsychological examination scores were noted in all cases. Recovery from psychiatric symptoms, however, was incomplete. Four patients could not work, and 3 needed psychological treatment due to behavioral abnormalities. HIV encephalopathy is not a lethal disease but the functional prognosis was very poor. New therapy is needed for HIV encephalopathy.

References

Jun 1, 1986·Annals of Neurology·B A NaviaR W Price
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Feb 13, 2001·Neurology·N SacktorUNKNOWN Multicenter AIDS Cohort Study
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Apr 10, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juan BerenguerUNKNOWN GESIDA 11/99 Study Group
Jun 26, 2003·AIDS·Gregory J DoreUNKNOWN National HIV Surveillance Committee

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