Clinical Features and Drug Characteristics of Patients with Generalized Fixed Drug Eruption in the West of Iran (2005-2014)

Dermatology Research and Practice
Hossein KavoussiReza Kavoussi

Abstract

Background. Generalized fixed drug eruption is a specific variant of fixed drug eruption with multifocal lesions. Diagnosis of this drug reaction is straightforward, but occasionally recognition of the causative drug is not possible. This study was aimed at evaluating the clinical features and culprit drugs in generalized fixed drug eruptions in the west of Iran. Method. This cross-sectional study was carried out on 30 patients with criteria of generalized fixed drug eruption over 9 years. Demographic, clinical, and drug intake information were collected. Results. Out of 30 patients (17 females and 13 males) with the mean age of 26.67 ± 10.21 years, 28 (93.3%) and 2 (6.7%) cases had plaque and bullous clinical presentation, respectively. Upper limbs were the most common (90%) site of involvement. The antibiotic group, especially cotrimoxazole (26.1%), was reported to be the most common offending drug, but the causative drug was not determined in 7 (23.3%) patients. Conclusion. Many cases of generalized fixed drug eruption firstly presented as limited lesions and led to generalized lesion due to repeated intake of the causative drug. No causative drug was found in some patients, which might be associated with concurrent intake o...Continue Reading

References

Jan 1, 1981·Dermatologica·S R Shukla
Dec 29, 1998·International Journal of Dermatology·A Mahboob, T S Haroon
Nov 13, 2001·American Journal of Clinical Dermatology·A Y Lee
Nov 26, 2003·Journal of the American Academy of Dermatology·Esen Ozkaya-Bayazit
Aug 17, 2006·International Journal of Dermatology·Virendra N Sehgal, Govind Srivastava
Jul 11, 2007·TheScientificWorldJournal·Nathan LawrentschukAndrew Troy
May 13, 2010·Drug Metabolism and Pharmacokinetics·Masahiro TohkinRyuichi Hasegawa
May 21, 2011·Acta Dermato-venereologica·Yu SawadaYoshiki Tokura
Jun 7, 2012·Bulletin de la Société de pathologie exotique·B SakaP Pitché
Dec 12, 2012·International Journal of Dermatology·A N Ognongo-Ibiaho, H L Atanda
Mar 19, 2014·Clinical and Experimental Dermatology·S OhtoshiT Nakada
Apr 23, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ceren CanMehtap Yazicioglu
Sep 18, 2014·Allergy, Asthma & Immunology Research·Jae-Woo JungHye-Ryun Kang
Dec 11, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·Y K HengY L Lim
May 27, 2015·Indian Dermatology Online Journal·Rohini SharmaNaina Dogra

❮ Previous
Next ❯

Citations

Jul 11, 2019·Contact Dermatitis·Najah Ben FadhelKarim Aouam
Nov 30, 2019·Einstein·Amanda Rocha Firmino PereiraPedro Giavina-Bianchi
Jan 21, 2021·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Alexandra PerksAna Poveda-Gallego

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Allergy, Asthma & Immunology Research
Jae-Woo JungHye-Ryun Kang
Annals of the Academy of Medicine, Singapore
J T Lim, H L Chan
Indian Journal of Dermatology
Amiya Kumar NathDevinder Mohan Thappa
© 2022 Meta ULC. All rights reserved