Clinical Features and Gene Mutations of Lung Cancer Patients 30 Years of Age or Younger

PloS One
Yuehong WangJianying Zhou

Abstract

Few studies examining the clinical features and gene mutations in lung cancer patients 30 years of age or younger have been published. A trend towards increasing morbidity has been noted in young patients; thus, an urgent need exists to explore this subgroup of patients. Patients aged ≤30 years with pathologically diagnosed lung cancer were retrospectively evaluated. We reviewed the clinical features, gene mutations and prognosis of each patient. Forty-one patients were included in this study. The mean age was 26.4±3.5 years. Cough, tightness/dyspnea and chest pain were common symptoms, and 58.5% of patients presented with advanced stages of lung cancer. Adenocarcinoma was the predominant histologic type noted in these young patients. Masses and nodules were the dominant imaging features observed upon lung computed tomography (CT). Thoracic lymphadenopathy occurred very frequently in these patients. Five of 6 patients with echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) gene fusions presented solid masses with no ground-glass opacity (GGO) and thoracic multifocal lymphadenopathy. Six of 22 (27.2%) cases contained EML4-ALK gene fusions. In addition, 5 of 22 (22.7%) patients harbored epide...Continue Reading

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Citations

May 31, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Stefania ScarpinoLuigi Ruco
Aug 8, 2019·BMC Cancer·Zhen ChenXiaodong Teng
Sep 3, 2018·Journal of Medical Case Reports·Lucia De MartinoLucia Quaglietta
Aug 22, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sarah VoggelInes B Brecht

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