Abstract
To analyze the course of maternal diseases and compare pregnancy outcomes in patients with systemic lupus erythematosus (SLE)-associated thrombocytopenia to patients without. Medical charts of 77 pregnancies in 73 SLE patients were systematically reviewed. Patients were divided into two groups according to the presence or absence of thrombocytopenia. Patients who are new onset SLE during pregnancy were also been studied. Thrombocytopenia was found in 18 (23.3%) of the pregnancies. SLE patients with thrombocytopenia during pregnancy had higher percentage of disease flaring (11/18 versus 14/59, p = 0.003) and SLE-Pregnancy Disease Activity Index (7.89 ± 6.192 versus 2.41 ± 3.3.89, p = 0.001) compared to patients without. Also, patients with thrombocytopenia had a higher percentage of pulmonary, cardiac and multiple organ system involvement. There was a statistically significant difference in preeclampsia and early onset hypertensive disorder induced before 34 weeks as well as the rate of live birth less than 34 weeks (33.3% versus 6.8%, p = 0.003 & 38.9% versus 13.6%, p = 0.018 & 16.7% versus 1.7%, p = 0.038). Patients with thrombocytopenia suffered from higher rate of pregnancy loss (22.2% versus 3.4%, p = 0.024) and neonatal de...Continue Reading
References
Nov 1, 1979·Arthritis and Rheumatism·A D SteinbergM Duvic
Dec 1, 1991·Arthritis and Rheumatism·M PetriJ Repke
Jan 1, 1990·Arthritis and Rheumatism·J D ReveilleG S Alarcón
Jan 1, 1990·Indian Journal of Pathology & Microbiology·N JayaramS Sehgal
Oct 1, 1983·Arthritis and Rheumatism·M H MillerD D Gladman
Jun 24, 1996·Archives of Internal Medicine·M M WardS Studenski
Jun 3, 1999·Medicine·R CerveraG R Hughes
Sep 9, 2004·Lupus·A H AlzeerE A Bamgboye
Jun 23, 2005·American Journal of Obstetrics and Gynecology·Eliza F ChakravartyMaurice L Druzin
Feb 8, 2006·Arthritis and Rheumatism·Michael M WardJames D Malley
Mar 29, 2006·Rheumatology·P D ZiakasM Voulgarelis
Feb 1, 2007·Arthritis and Rheumatism·Mónica FernándezUNKNOWN LUMINA Study Group
May 15, 2007·Rheumatic Diseases Clinics of North America·Michelle Petri
Jul 16, 2009·Clinical Reviews in Allergy & Immunology·Graziela CarvalheirasCarlos Vasconcelos
May 6, 2011·Lupus·L-W KwokEk Li
Aug 22, 2012·Nature Reviews. Rheumatology·Aisha Lateef, Michelle Petri
Jan 30, 2013·Clinical Rheumatology·Chunmei ZhaoNiansheng Yang
Nov 12, 2013·Lupus·N Patel, G M Mody
Citations
Apr 19, 2018·Lupus·K IchinoseA Kawakami
Jun 24, 2017·Blood·Douglas B Cines, Lisa D Levine
Dec 10, 2017·Hematology·Douglas B Cines, Lisa D Levine
May 2, 2020·Lupus·Yan-Mei MaoGuo-Cui Wu
Dec 4, 2016·Hematology·Terry B Gernsheimer
Dec 15, 2017·The Journal of Obstetrics and Gynaecology Research·Chong ZhangShi Chen
Jul 31, 2019·BMC Pregnancy and Childbirth·Xiaohan XuYuguang Huang
Dec 6, 2020·Journal of Clinical Pharmacy and Therapeutics·Qianru LengLujin Wu