Clinical features and outcomes of patients with hepatocellular carcinoma complicated with bile duct invasion

Clinical and Molecular Hepatology
Jihyun AnYung Sang Lee

Abstract

Little is known about the treatment or outcomes of hepatocellular carcinoma (HCC) complicated with bile duct invasion. A total of 247 consecutive HCC patients with bile duct invasion at initial diagnosis were retrospectively included. The majority of patients had Barcelona Clinic Liver Cancer (BCLC) stage C HCC (66.8%). Portal vein tumor thrombosis was present in 166 (67.2%) patients. Median survival was 4.1 months. Various modalities of treatment were initially employed including surgical resection (10.9%), repeated transarterial chemoembolization (TACE) (42.5%), and conservative management (42.9%). Among the patients with obstructive jaundice (n=88), successful biliary drainage was associated with better overall survival rate. Among the patients with BCLC stage C, overall survival differed depending on the initial treatment for HCC; surgical resection, TACE, systemic chemotherapy, and conservative management showed overall survival rates of 11.5, 6.0 ,2.4, and 1.6 months, respectively. After adjusting for confounders, surgical resection and repeated TACE were significant prognostic factors for HCC patients with bile duct invasion (hazard ratios 0.47 and 0.39, Ps <0.001, respectively). The survival of HCC patients with bile du...Continue Reading

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Citations

Dec 19, 2018·Clinical Nuclear Medicine·Wei ZhangYue Chen
Mar 27, 2021·Clinical Case Reports·Taku MatsumotoMasahiro Tominaga

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS

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