Clinical features and outcomes of patients with fever of unknown origin: a retrospective study

BMC Infectious Diseases
Yuting TanXiaochun Shi

Abstract

Few studies have reported the long-term clinical outcome of patients discharged with undiagnosed fever of unknown origin (FUO). In this study, the clinical features and outcomes of patients with unexplained fever were explored to improve our understanding of FUO. Patients diagnosed with FUO at admission and discharged without final diagnoses after systematic examination in the department of infectious diseases at Peking Union Medical College Hospital between 2004 and 2010 were followed up by telephone. Medical records were reviewed, and the clinical features and outcomes of patients for whom follow-up data were available were summarized. Between 2004 and 2010, 58 patients with follow-up data, who were diagnosed with FUO at admission and did not have a final diagnosis at discharge, were enrolled in this study. The median duration of follow-up was 518 (0.4-830) weeks, and the fever duration was 24.6 (6.7-763.2) weeks. Final diagnoses were established in 11 cases (19%), and the diagnostic methods included clinical diagnosis, diagnostic therapy, genetic screening and biopsy pathology. The fever in 35 patients (60%) subsided during hospitalization or after discharge. Their condition was stable and self-limited after long-term follow...Continue Reading

References

Feb 1, 1994·Internal Medicine·Y IikuniS Kashiwazaki
May 14, 2003·Archives of Internal Medicine·Steven VanderschuerenHerman Bobbaers
Feb 1, 1961·Medicine·R G PETERSDORF, P B BEESON
Jul 13, 2004·European Journal of Internal Medicine·Ian BuysschaertDaniël Knockaert
Feb 22, 2005·Current Drug Targets. Inflammation and Allergy·Mehmet Tunca, Huri Ozdogan
Jul 22, 2006·Scandinavian Journal of Infectious Diseases·Thierry Zenone
Aug 31, 2007·The Journal of Dermatology·Nobuo Kanazawa, Fukumi Furukawa
Jul 6, 2014·La Presse médicale·Adrien RobinePascal Sève
Feb 2, 2016·Journal of Infection in Developing Countries·Ahmed F KabapyEkram W Abd El Wahab

❮ Previous
Next ❯

Citations

Mar 14, 2021·British Journal of Haematology·Yee Ting Nicole YimMichael Brown
Apr 22, 2021·Minerva Endocrinology·Manuel SoldatoRaffaele Manna

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies

Related Concepts

Related Feeds

Adult-Onset Still's Disease

Adult-onset Still's disease (AOSD) is a form of Still's disease, a rare systemic autoinflammatory disease characterized by the classic triad of persistent high spiking fevers, joint pain, and a distinctive salmon-colored bumpy rash. Discover the latest research on AOSD here.