Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis

Yi-Jie GaoRong Zhou


Background: COVID-19 outbreak in Wuhan, China recently. It quickly spread throughout worldwide. In this study, we systematically reviewed the clinical features and outcomes of pregnant women with COVID-19.Methods: PubMed、Web of Science、EMBASE、MEDLINE were searched from January 1, 2020 to April 16, 2020. Case review of pregnant women infected with COVID-19 were included. Two reviewers screened 366 literatures and 14 studies included, four reviewers independently extracted the features of the literatures. We used random-effects model to analyze incidence (P) and 95% confidence interval (95%CI). Heterogeneity was assessed using the I2 statistic.Results: The meta- analysis included 236 pregnant women with COVID-19. The results were as follows: positive CT findings (71%; 95%CI, 0.49~0.93), cesarean section (65%; 95%CI, 0.42~0.87), fever (51%; 95%CI, 0.35~0.67), lymphopenia (49%; 95%CI, 0.29~0.70), coexisting disorders (33%; 95%CI, 0.21~0.44), cough (31%; 95%CI, 0.23~0.39), fetal distress (29%; 95%CI, 0.08~0.49), preterm labor (23%; 95%CI, 0.14~0.32), severe case or death (12%; 95%CI, 0.03~0.20). The subgroup analysis showed compared with nonpregnant patients, pregnant women with COVID-19 had significantly lower incidences of fever (...Continue Reading

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