Clinical features and outcomes of the patients with anti-glycyl tRNA synthetase syndrome.

Clinical Rheumatology
Yinli ZhangGuochun Wang

Abstract

To analyze the clinical features and outcomes of the patients with anti-glycyl tRNA synthetase (anti-EJ) syndrome in a large Chinese cohort. The medical records, imaging, and serologic data of patients with anti-EJ antibodies from the China-Japan Friendship Hospital database were retrospectively investigated. Anti-EJ antibodies were identified using immunoblot assay. Long-term follow-up was conducted. Anti-EJ antibodies were present in 46 (19.7%) of the 234 patients with antisynthetase syndrome (ASS), preceded by anti-Jo-1 and anti-PL-7 antibodies. The mean age of disease onset was 51.2 ± 15.9 years, and 69.6% of these patients were female. The most prevalent clinical feature was interstitial lung disease (ILD) (96.7%), which was also the most common initial manifestation, followed by fever (60.9%), mechanic's hands (56.5%), muscle involvement (50%), and Raynaud phenomenon (8.7%). Ten (21.7%) patients developed rapidly progressive ILD (RP-ILD). Organizing pneumonia (OP) on high-resolution computed tomography (HRCT) scans (OR = 37.5, p = 0.006) and a higher C-reactive protein-to-albumin ratio (CAR) (OR = 28.3, p = 0.01) were independent risk factors for RP-ILD. Muscular pathological features were heterogeneous. Concomitant infec...Continue Reading

References

May 1, 1986·The Journal of Experimental Medicine·C C BunnM B Mathews
Aug 1, 1984·The Journal of Experimental Medicine·M B MathewsR M Bernstein
Jul 13, 2004·Arthritis and Rheumatism·Lisa G RiderUNKNOWN International Myositis Assessment and Clinical Studies Group
Mar 11, 2011·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Joshua SolomonKevin K Brown
Feb 21, 2013·Annals of the Rheumatic Diseases·Rohit AggarwalChester V Oddis
Sep 17, 2013·American Journal of Respiratory and Critical Care Medicine·William D TravisUNKNOWN ATS/ERS Committee on Idiopathic Interstitial Pneumonias
Jan 16, 2014·Autoimmunity Reviews·Michael MahlerMarvin J Fritzler
Oct 2, 2015·Clinical Reviews in Allergy & Immunology·Minoru SatohEdward K L Chan
Jan 18, 2017·BMC Surgery·Peizhi YuwenYingze Zhang
May 4, 2017·The Journal of Rheumatology·Jingli ShiGuochun Wang

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Citations

Dec 29, 2020·Seminars in Arthritis and Rheumatism·Aleksandra Halina Opinc, Joanna Samanta Makowska

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