Clinical features and practical diagnosis of bullous pemphigoid

Immunology and Allergy Clinics of North America
E SchmidtL Borradori

Abstract

Bullous pemphigoid (BP) represents the most common autoimmune subepidermal blistering disease. BP typically affects the elderly and is associated with significant morbidity. It has usually a chronic course with spontaneous exacerbations. The cutaneous manifestations of BP can be extremely protean. While diagnosis of BP in the bullous stage is straightforward, in the non-bullous stage or in atypical variants of BP signs and symptoms are frequently non-specific with eg, only itchy excoriated, eczematous, papular and/or urticarial lesions that may persist for several weeks or months. Diagnosis of BP critically relies on immunopathologic examinations including direct immunofluorescence microscopy and detection of serum autoantibodies by indirect immunofluorescence microscopy or BP180-ELISA.

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Citations

Jan 30, 2014·Anais Brasileiros De Dermatologia·Eugenio Galdino de Mendonça Reis-FilhoCarmelia Matos Santiago Reis
Mar 13, 2015·Australian Dental Journal·T Yap, M McCullough
Jan 10, 2019·JAMA Dermatology·Khalaf Kridin, Reuven Bergman
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Oct 31, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Mareike WitteRalf Ludwig
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Sep 21, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Sascha StänderKhalaf Kridin

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