Clinical features and prognostic model for extranasal NK/T-cell lymphoma

European Journal of Haematology
Jae-Cheol JoC Suh

Abstract

The clinical features of extranodal natural killer (NK)/T-cell lymphoma (ENKL) that originates in extranasal sites are less well defined than those of ENKL that originates in nasal sites. Therefore, we compared the clinical characteristics and prognoses of patients with nasal ENKL and patients with extranasal ENKL. We retrospectively analyzed 117 consecutive patients with ENKL that included 89 (76.1%) with nasal and 28 (23.9%) with extranasal disease. Extranasal ENKL was associated with more adverse clinical features than nasal ENKL, which included the presence of B symptoms, stage III/IV disease, ≥2 extranodal sites, and involvement of regional lymph nodes and bone marrow. After a median follow-up of 33.1 months (range, 0.7-152.2 months), the median overall survival (OS) of patients with extranasal and nasal NK/T-cell lymphoma was 8.6 and 86.5 months, respectively. Multivariate analysis revealed that extranasal NK/T-cell lymphoma was a significant factor that affects OS. When patients with extranasal ENKL were classified into low-risk and high-risk categories according to the Korean Prognostic Index (KPI) and International Prognostic Index (IPI), these indices categorized the two groups with significantly different survival ou...Continue Reading

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Citations

Mar 19, 2014·PloS One·Rebeca MansoMiguel Ángel Piris
Feb 6, 2014·International Journal of Radiation Oncology, Biology, Physics·Qing-Feng LiuYe-Xiong Li
Aug 12, 2014·Medical Oncology·Etsuko YamazakiYoshiaki Ishigatsubo
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Jun 10, 2020·International Journal of Hematology·Satoshi IchikawaHideo Harigae
Jul 5, 2017·Experimental and Therapeutic Medicine·Haiyan YangXiaolin Li

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