Clinical Features and Treatment Outcomes among Children with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A 20-Year Study in a Tertiary Referral Hospital

Dermatology Research and Practice
Susheera ChatproedpraiSiriwan Wananukul

Abstract

To determine the probable causative factors, clinical features, and treatment outcomes of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS-TEN overlap in children. A 20-year database review of all children diagnosed with SJS/TEN/SJS-TEN overlap at the King Chulalongkorn Memorial Hospital, Thailand. 36 patients (M : F, 16 : 20) with the mean age of 9.2 ± 4.0 years were identified. There were 20 cases of SJS, 4 cases of SJS-TEN overlap, and 12 cases of TEN. Drugs were the leading cause for the diseases (72.3%); antiepileptics were the most common culprits (36.1%). Cutaneous morphology at presentation was morbilliform rash (83.3%), blister (38.9%), targetoid lesions (25.0%), and purpuric macules (2.8%). Oral mucosa (97.2%) and eye (83.3%) were the 2 most common mucosal involvements. Majority of the cases (77.8%) were treated with systemic corticosteroids, intravenous immunoglobulin, or both. Treatment outcomes between those who received systemic therapy and those who received only supportive care were comparable. Skin and eye were the principal sites of short-term and long-term complications. SJS/TEN are not common but are serious diseases which lead to significant morbidities in children. Early withdrawal...Continue Reading

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Citations

Oct 15, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Giulia LiccioliElio M Novembre
Feb 15, 2020·Indian Journal of Ophthalmology·Sharad Haribhau Shegaonkar
Aug 14, 2019·Clinical Practice and Cases in Emergency Medicine·Nikki B Canter, Lane M Smith
Apr 2, 2019·Pediatric Dermatology·Kathleen F O'BrienKalyani Marathe
Aug 28, 2020·F1000Research·Michele Ramien, Jennifer L Goldman

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