Clinical features, course, and outcomes of a UK cohort of pediatric moyamoya

Neurology
Sara C Tho-CalviBritish Paediatric Neurology Association Moyamoya Study group

Abstract

To describe characteristics and course of a large UK cohort of children with moyamoya from multiple centers and examine prognostic predictors. Retrospective review of case notes/radiology, with use of logistic regression to explore predictors of outcome. Eighty-eight children (median presentation age 5.1 years) were included. Thirty-six presented with arterial ischemic stroke (AIS) and 29 with TIA. Eighty had bilateral and 8 unilateral carotid circulation disease; 29 patients had posterior circulation involvement. Acute infarction was present in 36/176 hemispheres and chronic infarction in 86/176 hemispheres at the index presentation. Sixty-two of 82 with symptomatic presentation had at least one clinical recurrence. Fifty-five patients were treated surgically, with 37 experiencing fewer recurrences after surgery. Outcome was categorized as good using the Recovery and Recurrence Questionnaire in 39/85 patients. On multivariable analysis, presentation with TIA (odds ratio [OR] 0.09, 95% confidence interval [CI] 0.02-0.35), headache (OR 0.10, 95% CI 0.02-0.58), or no symptoms (OR 0.08, 95% CI 0.01-0.68) was less likely to predict poor outcome than AIS presentation. Posterior circulation involvement predicted poor outcome (OR 4.22...Continue Reading

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Citations

May 29, 2018·Current Treatment Options in Neurology·Si Un LeeTackeun Kim
Jun 27, 2019·Neurology·Dominique HervéHugues Chabriat
Sep 22, 2020·Brain Communications·Andrea RosiDarren B Orbach
Nov 13, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Hecheng YangHong Lu
Nov 7, 2020·Journal of Child Neurology·John R GattiLisa R Sun
May 8, 2021·Pediatric Neurology·Matsanga Leyila KasekaNomazulu Dlamini
Sep 23, 2021·Stroke; a Journal of Cerebral Circulation·Haogeng SunRui Tian

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