Clinical Features, Morbidity, and Risk Factors of Intestinal Pseudo-obstruction in Systemic Lupus Erythematosus: A Retrospective Case-control Study

The Journal of Rheumatology
Lingling ZhangXiao-Feng Zeng

Abstract

To analyze the epidemiology, clinical characteristics, and risk factors for systemic lupus erythematosus-related intestinal pseudo-obstruction (SLE-IPO). We retrospectively examined 85 patients with SLE with IPO as the case group and 255 randomly matched patients with SLE without any gastrointestinal manifestations as the control group, out of 4331 inpatients at the Peking Union Medical College Hospital (PUMCH) from 2003 to 2014. Over the last 11 years at PUMCH, the prevalence of IPO in patients with SLE was 1.96% and the in-hospital fatality rate was 7.1%. Of these patients, 57.6% presented with IPO as the initial affected system of SLE, and the rate of misdiagnosis was about 78%. Pyeloureterectasis was the most common complication (58.9%) in patients with SLE-IPO and the incidence of biliary tract dilation was 7.1%. Patients with SLE with IPO were always diagnosed at an earlier stage of SLE with a higher frequency of hematological disturbance, polyserositis, and hypocomplementemia. Pyeloureterectasis, hypocomplementemia, and elevated C-reactive protein levels in serum were independent risk factors for IPO in SLE disease. Patients with SLE-IPO with long IPO duration and those diagnosed during late stages of SLE or concurrent w...Continue Reading

References

Nov 1, 1981·The Medical Clinics of North America·M D Schuffler
May 22, 2008·World Journal of Gastroenterology : WJG·Alexandra AntonucciVincenzo Stanghellini
Jul 25, 2009·World Journal of Gastroenterology : WJG·Frederick-D ParkPradipta Ghosh
Jun 24, 2010·World Journal of Gastroenterology : WJG·Xin-Ping Tian, Xuan Zhang
May 18, 2011·World Journal of Gastrointestinal Pharmacology and Therapeutics·Giulia LeonardiSantino Marchi
Dec 8, 2011·Journal of Neurogastroenterology and Motility·Jaeyeon Kim, Nayoung Kim
Aug 30, 2014·World Journal of Gastroenterology : WJG·Carlos Alberto García LópezHaiko Nellen-Hummel

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Citations

Feb 11, 2011·Pediatric Rheumatology Online Journal·Carien B Gulay, Leonila F Dans
Sep 29, 2018·BMJ Case Reports·Yunfei YangDaniel Hancu
Jul 16, 2019·Medicine·Brittany L AdlerJulius Birnbaum
Dec 5, 2020·Case Reports in Gastrointestinal Medicine·Akwe NyaberaAdriana Abrudescu
Mar 27, 2021·Clinical Case Reports·Myriam AyariTaieb Jomni

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