Clinical features of aflatoxin B1-exposed patients with liver cancer and the molecular mechanism of aflatoxin B1 on liver cancer cells

Environmental Toxicology and Pharmacology
Rui ZhouRong Li

Abstract

Aflatoxin B1 (AFB1) induces hepatocellular carcinoma (HCC) through consumption of contaminated food in Southern China. Aldo-keto reductase-7A (AKR7A) functionally plays a potent role in the biodetoxification in the liver. In addition, hepatocellular lipid disorder has found to be closely linked to the development of HCC. This study was, therefore, designed to investigate the potent bioeffect of AKR7A on the lipid metabolism in AFB1-exposed hepatocellular carcinoma cells through assaying human cancerous samples and cell culture. In the baseline data, the HCC patients showed increased contents of AFB1 in sera and cancerous samples. In the clinical parameters, the HCC patients demonstrated changed lipid settings in sera. As revealed by immunostaining and immunoblotting, AFB1-elevated HCC sections showed marked down-regulation of AKR7A expression, accompanied with reduced ApoB expression and increased CD36, S6K1 expressions in the HCC. Studies in the human hepatocarcinoma line HepG2 also showed AFB1-exposure to increase ApoA1, LDL, TC, and TG contents; induce cell proliferation; and reduce hepatocellular AKR7A expression. Furthermore, AKR7A bioactivity was inactivated after treatment with perfluorooctane sulfonate (PFOS), an ApoB a...Continue Reading

References

Nov 21, 2009·Alimentary Pharmacology & Therapeutics·R Cabrera, D R Nelson
May 31, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Gerald N WoganJohn D Groopman
Jun 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Munzir M E AhmedJames Y Yang
Jan 28, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Lu-Nan QiLe-Qun Li
Mar 31, 2015·Life Sciences·Mariana R TavaresFernando M Simabuco
Nov 29, 2015·Biochemical Society Transactions·Stefan SchusterChristoph Kaleta
Dec 7, 2016·Journal of Clinical Lipidology·Lars H AndersenRolf L Andersen
Feb 6, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rong LiMin Su
Jun 22, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chao GuoRong Li
Jun 25, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yaqi DaiWentao Xu
Sep 10, 2017·Environmental Science and Pollution Research International·Xinmou WuBin Yang
Oct 17, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ka WuRong Li
Dec 5, 2017·Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer·Pinar ErkekogluBelmar Kocer-Gumusel
Jan 29, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ananditya NugrahaIvonne M C M Rietjens

❮ Previous
Next ❯

Citations

Dec 15, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Amanda Caroline Trassi ConteçottoMiguel Machinski Junior
Feb 6, 2021·Critical Reviews in Food Science and Nutrition·Alireza EmadiAnna Abdolshahi
May 19, 2021·Journal of Viral Hepatitis·Ferhat ArslanPasquale Pagliano
Jul 18, 2020·Ecotoxicology and Environmental Safety·Ionelia TaranuDaniela Eliza Marin
Aug 11, 2021·Signal Transduction and Targeted Therapy·Qing ZhuYuchen Jiao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolic Reprogramming (Keystone)

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cancer Metabolic Reprogramming

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

© 2021 Meta ULC. All rights reserved