Clinical features of anterior segment dysgenesis associated with congenital corneal opacities

Cornea
Chika ShigeyasuNoriyuki Azuma

Abstract

Anterior segment dysgenesis is one of the main causes of congenital corneal opacities. In this study, we investigated the clinical features and visual outcomes of patients with anterior segment dysgenesis in a large number of cases. The medical records of patients with congenital corneal opacities in relation to anterior segment dysgenesis seen in the National Center for Child Health and Development, Japan, between April 2002 and October 2009, were retrospectively studied. Records of 220 eyes of 139 patients were reviewed. Mean follow-up period was 5 years. Clinical diagnoses were Peters anomaly (72.7%), anterior staphyloma (11.4%), Rieger anomaly (7.7%), sclerocornea (6.4%), and others (1.8%). Visual acuity was measured in 61 patients. The best-corrected visual acuity in the better eye of bilaterally involved patients was 20/60 to 20/1000 (low vision according to the International Classification of Diseases, Ninth Revision, Clinical Modification) in 43.2% and less than 20/1000 (legally blind) in 24.3%. Fundus examination was performed in 82 eyes, and disorders were seen in 12 (12 of 82; 14.6%). Systemic abnormalities were present in 35 patients (35 of 139; 25.2%); a family history was present in 5 patients (5 of 139; 3.6%). Of...Continue Reading

References

Jul 1, 1975·Survey of Ophthalmology·G O WaringPeter R Laibson
Dec 1, 1992·Archives of Ophthalmology·E I Traboulsi, I H Maumenee
Jun 1, 1992·Ophthalmic Paediatrics and Genetics·U M Mayer
Jan 1, 1992·International Ophthalmology Clinics·P R Cotran, A M Bajart
Mar 1, 1991·Ophthalmology·C J PavlinF S Foster
Oct 15, 1990·American Journal of Ophthalmology·K D SteinsapirR C Tripathi
Feb 1, 1990·Ophthalmology·C J PavlinF S Foster
Jun 1, 1986·The British Journal of Ophthalmology·S R LeffC J Blair
Jan 1, 1968·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·P P Alkemade
Jul 1, 1996·The British Journal of Ophthalmology·A Churchill, A Booth
Jul 1, 1997·Ophthalmology·A Azuara-BlancoR P Wilson
Jun 1, 1997·The British Journal of Ophthalmology·H KobayashiT Kondo
Mar 7, 1998·American Journal of Medical Genetics·E Bermejo, M L Martínez-Frías
Sep 8, 1998·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·T AvitabileA Reibaldi
Jan 22, 2002·The British Journal of Ophthalmology·Ken K NischalD Rootman
Jul 17, 2004·Cornea·Renata A RezendeElisabeth J Cohen
Apr 29, 2006·Survey of Ophthalmology·Faisal IdreesPeng T Khaw
Dec 22, 2007·Seminars in Ophthalmology·Jessica Ciralsky, Kathryn Colby
Apr 23, 2008·International Ophthalmology Clinics·Mona Harissi-Dagher, Kathryn Colby
Nov 20, 2008·Clinical & Experimental Ophthalmology·Jose Luiz Branco RamosDavid Huang

Citations

Jun 5, 2014·Human Molecular Genetics·Xiaohe YanJochen Graw
Dec 12, 2012·Veterinary Ophthalmology·Hassan HamoudiSteffen Heegaard
Feb 17, 2017·Cornea·Haruna YoshikawaShigeru Kinoshita
Nov 15, 2017·Clinical Genetics·J PlaisanciéN Chassaing
Oct 1, 2016·Scientific Reports·Johanne DubailSuneel S Apte
Nov 7, 2019·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Hind M AlkatanMosa Al Harby
Apr 14, 2020·Journal of Ophthalmology·Wen-Si ChenLan-Xiang Hu
Nov 15, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Charlotte SchrammDorothea Besch
Apr 29, 2016·International Journal of Molecular Medicine·Yang YangQi Mei
May 23, 2017·The Journal of Veterinary Medical Science·Reiichiro SatoHiroo Madarame
Dec 19, 2017·The Journal of Veterinary Medical Science·Sangwan ParkKangmoon Seo
Feb 9, 2021·Molecular Genetics and Metabolism Reports·Bharesh K ChauhanKen K Nischal

Related Concepts

Anterior Eyeball Segment Structure
Corneal Opacity
Eye Abnormalities
Retrospective Studies
Visual Acuity
Congenital Abnormality
Cell Differentiation Process
Classification
Embryonic Development
Eye

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