Clinical features of celiac disease: a prospective birth cohort.

Pediatrics
Daniel AgardhTEDDY Study Group

Abstract

To investigate clinical features of celiac disease (CD) and their association with risk factors for CD in a genetic risk birth cohort. Children from 6 clinical centers in 4 countries positive for HLA-DR3-DQ2 or DR4-DQ8 were annually screened for tissue transglutaminase antibodies (tTGA) and assessed for symptoms by questionnaires. Associations of symptoms with anthropometrics, known risk factors for CD, tTGA levels, and mucosal lesions in those biopsied were examined. Of 6706 screened children, 914 developed persistent positive tTGA, 406 underwent biopsies, and 340 had CD. Compared with age-matched tTGA-negative children, those with persistent tTGA were more likely to have symptoms at 2 (34% vs 19%, P < .001) and 3 years of age (28% vs 19%, P = .009) but not at 4 years (27% vs 21%, NS). Z-scores for height, weight, and BMI did not differ between groups. In children with persistent tTGA, having ≥ 1 symptom was associated with family history of CD (odds ratio = 2.59, 95% confidence interval, 1.21-5.57) but not with age, gender, or HLA-DR3-DQ2 homozygosity. At seroconversion, tTGA levels were higher in symptomatic than asymptomatic children (P < .001), in those from CD families (P < .001), and in US participants (P < .001) but not...Continue Reading

References

Sep 16, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G Oberhuber
Jun 7, 2002·Journal of Pediatric Gastroenterology and Nutrition·Paul ZubillagaJuan Carlos Vitoria
Apr 12, 2005·Clinical Pediatrics·Michael A D'AmicoPeter H R Green
Feb 18, 2006·Scandinavian Journal of Gastroenterology·Hannele KarinenMarkku Laakso
Nov 30, 2006·Annals of the New York Academy of Sciences·William A HagopianBeena Akolkar
Dec 28, 2006·Scandinavian Journal of Gastroenterology·Rita-Désirée JoresMauro Congia
Oct 26, 2007·The New England Journal of Medicine·Peter H R Green, Christophe Cellier
Jun 23, 2011·Journal of Clinical Gastroenterology·Federico BiagiGino R Corazza
Dec 27, 2011·Journal of Pediatric Gastroenterology and Nutrition·S HusbyUNKNOWN European Society for Pediatric Gastroenterology, Hepatology, and Nutrition
Jan 24, 2012·Journal of Pediatric Gastroenterology and Nutrition·Klaus GiersiepenUNKNOWN ESPGHAN Working Group on Coeliac Disease Diagnosis
May 23, 2012·Journal of Pediatric Gastroenterology and Nutrition·Sampsa KinosKatri Kaukinen
Oct 16, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Juha TaavelaKatri Kaukinen
Nov 14, 2013·World Journal of Gastroenterology : WJG·Amani MubarakRoderick H J Houwen
Jan 15, 2014·Pediatrics·Anna RosénAnneli Ivarsson
Feb 11, 2014·Journal of Pediatric Gastroenterology and Nutrition·Joaquim Calvo LermaCarmen Ribes-Koninckx
Jul 2, 2014·BMC Pediatrics·Maria van der PalsAnnelie Carlsson
Jul 6, 2014·The New England Journal of Medicine·Edwin LiuUNKNOWN TEDDY Study Group
Oct 2, 2014·The New England Journal of Medicine·Elena LionettiUNKNOWN SIGENP (Italian Society of Pediatric Gastroenterology, Hepatology, and Nutrition) Working Group on Weaning and CD Risk
Oct 2, 2014·The New England Journal of Medicine·Sabine L VriezingaM Luisa Mearin

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Citations

Jul 29, 2017·Journal of Pediatric Gastroenterology and Nutrition·Sibylle KoletzkoUNKNOWN TEDDY Study Group
Mar 21, 2017·Journal of Pediatric Gastroenterology and Nutrition·Sara BjörckDaniel Agardh
Jun 1, 2017·Journal of Pediatric Gastroenterology and Nutrition·Nancy BabioJordi Salas-Salvadó
Jun 15, 2017·Archives of Disease in Childhood·Christian R KahrsKetil Størdal
Jun 20, 2018·Acta Paediatrica·Laura Kivelä, Kalle Kurppa
Oct 26, 2018·Current Diabetes Reports·Marian RewersUNKNOWN TEDDY Study Group
Nov 30, 2018·HLA : Immune Response Genetics·Blanka Vidan-Jeras
Feb 15, 2019·BMJ : British Medical Journal·Christian R KahrsKetil Størdal
Aug 14, 2019·JAMA : the Journal of the American Medical Association·Carin Andrén AronssonUNKNOWN TEDDY Study Group
Aug 12, 2017·Italian Journal of Pediatrics·Michele AriglianiPaola Cogo
Oct 1, 2019·Journal of Pediatric Gastroenterology and Nutrition·Steffen HusbyMargreet Wessels
Dec 11, 2019·Journal of Pediatric Gastroenterology and Nutrition·Norelle R ReillyPeter H Green
Nov 19, 2019·ACG Case Reports Journal·Anam BashirPratikkumar Patel
Sep 18, 2020·Scandinavian Journal of Gastroenterology·Marisa G StahlKarl Mårild
Aug 26, 2015·Nature Reviews. Gastroenterology & Hepatology·Knut E A Lundin, Cisca Wijmenga
Jun 8, 2017·Journal of Gastroenterology·Michelle JansenJohanna Escher
Dec 7, 2018·Frontiers in Pediatrics·Jason A Tye-DinDaniel Agardh
Aug 7, 2019·Nutrients·Ulla UusitaloUNKNOWN TEDDY Study Group
Jan 25, 2020·Journal of Pediatric Gastroenterology and Nutrition·Norelle R ReillyPeter H Green
May 2, 2020·Archives of Disease in Childhood·Renata AuricchioLuigi Greco
Jul 25, 2020·Digestive Diseases and Sciences·Laura AiraksinenKalle Kurppa
Aug 25, 2015·Journal of Pediatric Gastroenterology and Nutrition·Sara BjörckDaniel Agardh
Mar 25, 2017·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Alessandra CamarcaCarmen Gianfrani
Sep 8, 2017·Frontiers in Cellular and Infection Microbiology·Yalda LuceroMagdalena Araya
Apr 16, 2020·Nutrients·Giorgia ViciValeria Polzonetti
Dec 29, 2018·Alimentary Pharmacology & Therapeutics·Valma FuchsKatri Kaukinen
Dec 5, 2015·Scandinavian Journal of Gastroenterology·Caroline MonténDaniel Agardh
Oct 13, 2018·Digestive Diseases and Sciences·Omer Faruk BeserUNKNOWN Northern Cyprus Celiac Study Group
Jul 24, 2020·The American Journal of Gastroenterology·Marisa G StahlUNKNOWN ASK Study Group
Sep 12, 2015·Deutsches Ärzteblatt International·Martin W LaassSibylle Koletzko
Jan 4, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Ida GustafssonKalle Kurppa
Dec 12, 2020·Journal of Pediatric Gastroenterology and Nutrition·Petra RiznikJernej Dolinsek
Nov 13, 2020·The American Journal of Gastroenterology·German TapiaKetil Størdal
Apr 4, 2021·Acta Paediatrica·Ketil Størdal
May 14, 2021·The American Journal of Gastroenterology·German TapiaKetil Størdal
May 4, 2021·Journal of Pediatric Gastroenterology and Nutrition·Abdulrahman Al-HussainiRiccardo Troncone
Jun 17, 2015·Pediatrics·Yekaterina ShermanThomas J A Lehman
Mar 4, 2015·Pediatrics·Richard J Noel
Feb 22, 2017·Pediatrics·Laura B SmithUNKNOWN TEDDY study group

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