Clinical features of dermatomyositis associated with anti-MDA5 antibodies by age.

Modern Rheumatology
Koichi YamaguchiToshitaka Maeno

Abstract

Anti-melanoma differentiation-associated gene 5 (MDA5) autoantibody-positive and age at onset ≥60 years are poor prognosis factors in polymyositis (PM) and dermatomyositis (DM) associated with interstitial lung disease (ILD) among Japanese patients. However, the influence of age on the clinical features of anti-MDA5 autoantibody-positive patients with DM remains unclear. We retrospectively examined 40 patients with DM and anti-MDA5 autoantibodies according to age. We compared patients aged <60 and ≥60 years with respect to clinical features including laboratory test findings, high-resolution lung computed tomography data, treatment content, and complications such as infections and prognosis. We also examined clinical features between surviving and deceased patients in the older patient group. Of 40 enrolled patients, 13 were classified as old and 27 as young. Older patients had significantly fewer clinical symptoms including arthralgia/arthritis (p < .01), skin ulceration (p = .02), and higher mortality than younger patients (p = .02) complicated with rapidly progressive ILD (RP-ILD), combination immunosuppressive therapy, and strictly controlled infections. Clinical features and mortality of anti-MDA5 autoantibody-positive DM ...Continue Reading

References

Apr 12, 2001·The British Journal of Dermatology·Y J ChenJ L Shen
Sep 22, 2006·Rheumatology·M Gaubitz
Sep 15, 2010·Rheumatology·I-Jung ChenKuang-Hui Yu
Jun 3, 2011·Respiratory Medicine·Kiminobu TanizawaMichiaki Mishima
Sep 18, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Toru AraiSeiji Hayashi
Feb 26, 2013·Arthritis Care & Research·John C HallLisa Christopher-Stine
May 1, 2013·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Ran Nakashima, Tsuneyo Mimori
Jul 31, 2014·European Journal of Dermatology : EJD·Toshifumi YamaokaIchiro Katayama
Feb 27, 2016·The European Respiratory Journal·Paolo SpagnoloVincent Cottin
Apr 23, 2016·Chest·Julie MorissetJoyce S Lee
Jan 13, 2018·Arthritis Research & Therapy·Yumiko SugiyamaHideaki Nakajima

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