Clinical features of gastroduodenal ulcer in Japanese patients taking low-dose aspirin.

Digestive Diseases and Sciences
Junichi IwamotoYasushi Matsuzaki

Abstract

The risks of peptic ulcer complications increase in association with low-dose aspirin (LDA) use. The endoscopic findings and clinical features of gastroduodenal ulcer have not been thoroughly investigated in patients taking LDA. We classified 1,041 gastroduodenal ulcer patients into three groups [patients taking LDA (group A), patients taking nonaspirin nonsteroidal anti-inflammatory drug (NSAID) (group N), and patients taking neither aspirin nor nonaspirin NSAID (group C)] and 241 bleeding gastroduodenal ulcer patients into three corresponding groups (groups a, n, and c). We investigated the clinical features, endoscopic characteristics, and endoscopic treatment of the hemorrhagic lesion in the gastroduodenal ulcer patients taking LDA and compared them with those of the other groups. The frequency of bleeding events such as hematemesis, melena, and anemia was significantly higher in group A and N than in group C. The percentage of ulcers located in the antrum was higher in group A and N than in group C, and also higher in group a and n than in group c. The percentage of ulcers located in the body, fundus, and cardia was significantly higher in the bleeding patients than in all gastroduodenal ulcer patients. The percentage of c...Continue Reading

References

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Citations

Sep 1, 1996·Trends in Neurosciences·M Lutchman, G A Rouleau
Apr 5, 2013·World Journal of Gastroenterology : WJG·Junichi IwamotoYasushi Matsuzaki
Oct 22, 2010·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Jin Joo KimIn Sung Song
Oct 27, 2018·BMJ : British Medical Journal·Emma SverdénJesper Lagergren
Feb 26, 2014·World Journal of Gastrointestinal Endoscopy·Mustafa Atar, Abdurrahman Kadayifci

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