Clinical features of mixed physiology of constriction and restriction: echocardiographic characteristics and clinical outcome

European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology
Hirotsugu YamadaAllan L Klein

Abstract

An entity of patients with mixed physiology of constriction and restriction has been reported, however, the characteristics of these patients have not been well documented. We evaluated the clinical features and the outcome of these patients. Study subjects consisted of 38 patients (57+/-14 years, 8 females, 30 males) who were diagnosed as having mixed physiology based on transthoracic and/or transesophageal echocardiography, MRI (or CT), cardiac catheterization, endomyocardial biopsy and/or surgical findings. Prior radiation therapy was the most frequent (50%) cause of mixed physiology followed by coronary artery bypass graft without prior radiation (24%) and heart transplantation (8%). The respiratory variation of peak early diastolic transmitral flow velocity by pulsed Doppler transesophageal echocardiography was 10.7% in patients with sinus rhythm and 18.1% in patients with atrial arrhythmia. Pericardial thickening was noted adjacent to the right-sided chambers in 19 patients, left-sided chambers in 10 patients, or both in 9 patients. All-cause 5-year mortality was 40% and unrelated to age, etiology, left ventricular systolic function and therapeutic course. There was a statistically significant difference (p<0.01) between ...Continue Reading

Citations

Jul 20, 2007·Heart·Emma L IvensRobert R Moss
Aug 28, 2009·Cardiovascular Ultrasound·Carmen GinghinaBogdan A Popescu
Nov 26, 2016·Journal of the American College of Cardiology·Jeffrey B GeskeBernard J Gersh
Sep 11, 2010·Expert Review of Cardiovascular Therapy·Ronald MastouriJo Mahenthiran
Jul 30, 2014·Nature Reviews. Cardiology·Faisal F SyedJae K Oh

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