Clinical features of neocortical temporal lobe epilepsy

Annals of Neurology
S V PaciaW K Doyle

Abstract

Few studies have examined the clinical features of neocortical temporal lobe epilepsy (NTLE) in carefully selected patients. We reviewed records from 21 patients with NTLE, defined by intracranial electroencephalogram (EEG), who have been seizure free for 1 year or more following temporal lobectomy. The mean age of onset at the time of first seizure was 14 years (range, 1-41 years). Febrile seizures were reported in only 2 patients (9.5%). In contrast to prior mesial temporal lobe epilepsy (MTLE) studies, seizure-free intervals between the initial cerebral insult or first seizure and habitual seizures were uncommon. Possible or known risk factors for epilepsy were reported in 13 of 21 patients (62%). Fifteen (71%) patients reported auras, with experiential phenomena being the most common type. Magnetic resonance imaging was normal or nonspecific in 15 patients, revealed mild hippocampal atrophy in 2, tumors in 2, and heterotopic gray matter and hippocampal atrophy in 1, and cortical dysgenesis in 1. Neuropsychological testing showed deficits consistent with the seizure focus in 13 patients (62%), and Wada test showed ipsilateral memory deficits in 10 (48%). The most common behavioral manifestation was a motionless stare at icta...Continue Reading

References

Mar 11, 1975·Brain : a Journal of Neurology·J EngelM A Falconer
Jan 11, 1992·Acta Neurologica Scandinavica. Supplementum·J Engel
Jul 1, 1988·Epilepsia·H M MaldonadoR W Rand
Jan 1, 1966·Southern Medical Journal·W P Wilson, B S Harris
Apr 1, 1994·Annals of Neurology·M DuchownyL Alvarez
Jan 1, 1993·Annals of Neurology·W T BlumeP Stenerson
Apr 1, 1996·Epilepsia·J S Ebersole, S V Pacia
Dec 1, 1963·Brain : a Journal of Neurology·W PENFIELD, P PEROT
Mar 1, 1964·Archives of Neurology·M A FALCONERJ A CORSELLIS

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Citations

Dec 21, 2006·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·R P CarneT J O'Brien
Jan 21, 2000·Epilepsy Research·G WunderlichR J Seitz
Nov 25, 2003·Seizure : the Journal of the British Epilepsy Association·J JanszkyA Ebner
Nov 30, 2007·Nature Clinical Practice. Neurology·Ruben Kuzniecky, Orrin Devinsky
Oct 3, 2012·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Jeffrey D Kennedy, Stephan U Schuele
Mar 1, 2012·Journal of Epilepsy Research·Pamela SongSeung Bong Hong
Aug 31, 2012·Epilepsy Research and Treatment·Adil HarroudDang Khoa Nguyen
Sep 7, 2012·Epilepsy Research and Treatment·Eduard BercoviciSeyed M Mirsattari
Oct 6, 2016·Epilepsy Research and Treatment·Marcus C NgAndrew J Cole
Mar 18, 2017·Acta neurologica Belgica·Riëm El Tahry, Irene Zhong Wang
Mar 14, 2007·Current Opinion in Neurology·Deepak Madhavan, Ruben Kuzniecky
Nov 27, 1999·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·S V Pacia, J S Ebersole
Nov 27, 1999·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Won Young JungOrrin Devinsky
Dec 2, 2004·Epilepsia·Louis MaillardFabrice Bartolomei
Jun 1, 2021·Epilepsy & Behavior : E&B·Huan-Guang LiuWen-Han Hu

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