Clinical features of patients with beta-lactamase producing Haemophilus influenzae isolated from sputum

The Journal of Antimicrobial Chemotherapy
S R JohnsonJ T Macfarlane

Abstract

Ampicillin resistance amongst isolates of Haemophilus influenzae is of increasing concern but its clinical impact is unclear. We performed a retrospective study of 34 hospital patients with lower respiratory tract infection (LRTI) caused by beta-lactamase positive (beta+) H. influenzae and compared these with 34 control patients with LRTI caused by beta-lactamase negative (beta-) strains. Chronic obstructive pulmonary disease was the most common underlying condition in both groups (beta+ 23/24, beta- 25/34). A recent course of antibiotics, especially ampicillin/amoxycillin, was significantly (P < 0.05) more common in the beta+ group (beta+ 17/34, beta- 3/34). Other pathogens were isolated more frequently in the beta+ group (beta+ 10/34, beta- 4/34). There was no difference in outcome between the two groups.

Citations

Aug 29, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D Steinke, P Davey
Apr 16, 2021·Open Forum Infectious Diseases·Saeed ShoarDaniel M Musher

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