Abstract
The aims of this study were to evaluate the clinical characteristics, laboratory data, and treatment of the cytomegalovirus (CMV)-associated thrombocytopenia in infants aged younger than 12 months and to investigate the possible relationship between genotypes of glycoprotein B (gB) and glycoprotein H (gH) and CMV-associated thrombocytopenia. Infants with positive identification of cytomegalovirus (CMV) and thrombocytopenia, being treated at Hubei Maternal and Child Health Hospital from January 2015 to June 2019 were included. Genotype of gB and gH analysis were done by nested polymerase chain reaction (nPCR) and restrictions length polymorphism. The prevalence of CMV congenital, perinatal, and postnatal infection were 1.4% (76/5428), 29.1% (378/1301), and 41.8% (243/581), respectively. A total of 29 immunocompetent patients with CMV-associated thrombocytopenia were analyzed, including 7 (9.2%, 7/76) congenital infections, 14 (3.7%, 14/378) perinatal infections, and 8 (3.3%, 8/243) postnatal infections. Platelet count at diagnosis <20 × 109/L was the common hematologic finding of CMV-associated thrombocytopenia in perinatal infection (1/7 congenital infection vs. 10/14 perinatal infection vs. 3/8 postnatal infection, Chi-square ...Continue Reading
References
Jul 9, 2002·Clinical and Experimental Immunology·J LipesM M Newkirk
Aug 4, 2004·British Journal of Haematology·Adam S Levy, James Bussel
May 23, 2006·Intervirology·Zhong Sheng YuZheng Yan Zhao
Jul 12, 2008·Scandinavian Journal of Infectious Diseases·Zhong Sheng YuZheng Yan Zhao
Nov 14, 2008·Blood·Francesco RodeghieroJames N George
Oct 23, 2009·Blood·Drew ProvanDavid J Kuter
Nov 4, 2010·Fetal and Pediatric Pathology·Zheng ShenZhong Sheng Yu
Sep 18, 2015·Journal of Virology·Flavia ChiuppesiDon J Diamond
Nov 28, 2015·Virology Journal·Maria-Cristina ArcangelettiAdriana Calderaro
Mar 8, 2016·Journal of Medical Virology·Davod KhalafkhanyMorteza Motazakker
Sep 16, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Noriko MitsuikiMasayuki Nagasawa
Feb 6, 2017·Medicine·Shiwen WangChengbin Wang
Mar 14, 2017·Journal of Microbiology and Biotechnology·Qing'e JinShanna Wu
Mar 16, 2017·The Lancet Infectious Diseases·William D RawlinsonWendy J van Zuylen
Jun 27, 2017·Frontiers in Pediatrics·Ines MackSven Wellmann
Mar 13, 2018·The Journal of Clinical Investigation·Kang YuDeborah N Burshtyn
Jul 3, 2018·Blood Research·Min Ji JinJeong Ok Hah
Oct 13, 2018·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ganna GalitskaSanto Landolfo
Dec 1, 2018·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Laura BarradoLola Folgueira
Feb 28, 2019·The American Journal of Tropical Medicine and Hygiene·Sevan N AlwanBrian L Wickes
Jun 18, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Nina Dwi PutriDodi Safari
Jul 3, 2019·BMJ Paediatrics Open·Paulo PaixãoMaria Teresa Neto