Clinical Features, Treatment Courses, and Distribution of Cytomegalovirus Genotypes among Thrombocytopenia Patients Aged Younger than 12 Months.

American Journal of Perinatology
Hongbo HuKun Chen

Abstract

The aims of this study were to evaluate the clinical characteristics, laboratory data, and treatment of the cytomegalovirus (CMV)-associated thrombocytopenia in infants aged younger than 12 months and to investigate the possible relationship between genotypes of glycoprotein B (gB) and glycoprotein H (gH) and CMV-associated thrombocytopenia. Infants with positive identification of cytomegalovirus (CMV) and thrombocytopenia, being treated at Hubei Maternal and Child Health Hospital from January 2015 to June 2019 were included. Genotype of gB and gH analysis were done by nested polymerase chain reaction (nPCR) and restrictions length polymorphism. The prevalence of CMV congenital, perinatal, and postnatal infection were 1.4% (76/5428), 29.1% (378/1301), and 41.8% (243/581), respectively. A total of 29 immunocompetent patients with CMV-associated thrombocytopenia were analyzed, including 7 (9.2%, 7/76) congenital infections, 14 (3.7%, 14/378) perinatal infections, and 8 (3.3%, 8/243) postnatal infections. Platelet count at diagnosis <20 × 109/L was the common hematologic finding of CMV-associated thrombocytopenia in perinatal infection (1/7 congenital infection vs. 10/14 perinatal infection vs. 3/8 postnatal infection, Chi-square ...Continue Reading

References

Aug 4, 2004·British Journal of Haematology·Adam S Levy, James Bussel
Jul 12, 2008·Scandinavian Journal of Infectious Diseases·Zhong Sheng YuZheng Yan Zhao
Nov 4, 2010·Fetal and Pediatric Pathology·Zheng ShenZhong Sheng Yu
Nov 28, 2015·Virology Journal·Maria-Cristina ArcangelettiAdriana Calderaro
Sep 16, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Noriko MitsuikiMasayuki Nagasawa
Jun 27, 2017·Frontiers in Pediatrics·Ines MackSven Wellmann
Mar 13, 2018·The Journal of Clinical Investigation·Kang YuDeborah N Burshtyn
Oct 13, 2018·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ganna GalitskaSanto Landolfo
Dec 1, 2018·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Laura BarradoLola Folgueira
Feb 28, 2019·The American Journal of Tropical Medicine and Hygiene·Sevan N AlwanBrian L Wickes
Jun 18, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Nina Dwi PutriDodi Safari

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.