Clinical Features, Virus Identification, and Sinusitis as a Complication of Upper Respiratory Tract Illness in Children Ages 4-7 Years

The Journal of Pediatrics
Gregory P DeMuriEllen R Wald

Abstract

To determine the rate of sinusitis complicating upper respiratory tract illnesses (URIs) in children. We prospectively identified the clinical, virologic, and epidemiologic characteristics of URIs in a population of 4- to 7-year-old children followed for 1 year. This was an observational cohort study in 2 primary care pediatric practices in Madison, Wisconsin. Nasal samples were obtained during 4 asymptomatic surveillance visits and during symptomatic URIs. A polymerase chain reaction-based assay for 9 respiratory viruses was performed on nasal samples. A diagnosis of sinusitis was based on published criteria. Two hundred thirty-six children ages 48-96 months were enrolled. A total of 327 URIs were characterized. The mean number of URIs per child was 1.3 (range 0-9) per year. Viruses were detected in 81% of URIs; rhinovirus (RV) was most common. Seventy-two percent of URIs were resolved clinically by the 10th day. RV-A and RV-C were detected more frequently at URI visits; RV-B was detected at the same rate for both asymptomatic surveillance visits and URI visits. Sinusitis was diagnosed in 8.8% of symptomatic URIs. Viruses were detected frequently (33%) in samples from asymptomatic children. Sinusitis occurred in 8.8% of sympto...Continue Reading

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Citations

Nov 10, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gregory P DeMuriEllen R Wald
Oct 12, 2018·Pediatric Annals·Harbir Singh Arora
Mar 24, 2018·The Pediatric Infectious Disease Journal·Ellen R Wald, Gregory P DeMuri
Jan 17, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gregory P DeMuriEllen R Wald
Aug 21, 2019·International Forum of Allergy & Rhinology·Usmaan BasharatEugene H Chang
May 13, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Sean M McDermottPatrick C Walz
Aug 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ellen R WaldDaniele Y Gusland
Oct 1, 2019·International Journal of Pediatric Otorhinolaryngology·Dylan A LevyRodney J Schlosser
Nov 26, 2020·International Forum of Allergy & Rhinology·Richard R OrlandiBing Zhou
Mar 24, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Kenji KishimotoKunihiko Kobayashi
May 4, 2021·The Laryngoscope·Shoichi Sawada, Shigenori Matsubara

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