Clinical findings and outcomes in patients with possible usual interstitial pneumonia

Respiratory Medicine
Jin Wook LeeWon-Il Choi

Abstract

Patients with possible usual interstitial pneumonia (UIP) constitute a substantial group, and their clinical characteristics and outcomes are not well defined. We compared the clinical characteristics and survival between patients with possible UIP and the UIP pattern. We evaluated 62 patients with possible UIP and 544 patients with the UIP pattern. Both groups were diagnosed by clinical characteristics and high-resolution computed tomography (HRCT) findings. Two radiologists performed radiological evaluation based on the new idiopathic pulmonary fibrosis (IPF) guidelines. Two risk-stratification methods were used to compare UIP pattern and possible UIP patients. The groups had similar demographic and clinical characteristics. Pulmonary function tests revealed no significant differences in lung volumes between the 2 groups. However, DLCO was significantly lower with the UIP pattern than with possible UIP (p = 0.004). Multivariate analysis showed age, sex, and carbon monoxide diffusing capacity (DLCO) as important independent variables for survival. The UIP HRCT pattern did not affect survival (hazard ratio, 0.83; 95% confidence interval, 0.51-1.24; p = 0.32). Possible UIP was not associated with prognosis when independent predi...Continue Reading

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Citations

Jul 28, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Toru AraiYoshikazu Inoue
Jun 23, 2016·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuDavid M Hansell
Dec 31, 2016·American Journal of Respiratory and Critical Care Medicine·Joao A de Andrade, Tracy Luckhardt
Dec 6, 2018·Allergy·Iñigo OjangurenXavier Muñoz
Nov 22, 2017·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Pedro Paulo Teixeira E Silva TorresEdson Marchiori
Aug 24, 2017·Respiratory Research·Miia KärkkäinenRiitta Kaarteenaho
Aug 8, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Yet H KhorAnne E Holland
Sep 19, 2020·European Clinical Respiratory Journal·Charlotte HyldgaardElisabeth Bendstrup
Nov 12, 2020·Respiratory Research·Byoung Soo KwonJin Woo Song

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