Clinical Frailty Scale (CFS) reliably stratifies octogenarians in German ICUs: a multicentre prospective cohort study

BMC Geriatrics
Johanna Maria MuessigChristian Jung

Abstract

In intensive care units (ICU) octogenarians become a routine patients group with aggravated therapeutic and diagnostic decision-making. Due to increased mortality and a reduced quality of life in this high-risk population, medical decision-making a fortiori requires an optimum of risk stratification. Recently, the VIP-1 trial prospectively observed that the clinical frailty scale (CFS) performed well in ICU patients in overall-survival and short-term outcome prediction. However, it is known that healthcare systems differ in the 21 countries contributing to the VIP-1 trial. Hence, our main focus was to investigate whether the CFS is usable for risk stratification in octogenarians admitted to diversified and high tech German ICUs. This multicentre prospective cohort study analyses very old patients admitted to 20 German ICUs as a sub-analysis of the VIP-1 trial. Three hundred and eight patients of 80 years of age or older admitted consecutively to participating ICUs. CFS, cause of admission, APACHE II, SAPS II and SOFA scores, use of ICU resources and ICU- and 30-day mortality were recorded. Multivariate logistic regression analysis was used to identify factors associated with 30-day mortality. Patients had a median age of 84 [IQ...Continue Reading

References

Sep 1, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kenneth RockwoodArnold Mitnitski
Jan 26, 2011·Critical Care : the Official Journal of the Critical Care Forum·Antoine RochLaurent Papazian
Feb 25, 2011·Critical Care : the Official Journal of the Critical Care Forum·Robert C McDermidSean M Bagshaw
Jun 8, 2011·Intensive Care Medicine·Lilian MinneAmeen Abu-Hanna
Feb 12, 2013·Lancet·Andrew CleggKenneth Rockwood
Mar 22, 2014·Intensive Care Medicine·Robert C McDermid, Sean M Bagshaw
Apr 23, 2015·Critical Care Medicine·Daren HeylandUNKNOWN Canadian Researchers at the End of Life Network
Aug 3, 2016·Journal of Critical Care·Ian M BallIan G Stiell
Sep 13, 2016·Critical Care Medicine·Finn H AndersenReidar Kvåle
Dec 7, 2016·American Journal of Respiratory and Critical Care Medicine·Nathan E BrummelE Wesley Ely
Jul 6, 2017·Intensive Care Medicine·John MuscedereKenneth Rockwood
Jul 12, 2017·Journal of the American College of Cardiology·Jonathan AfilaloLouis P Perrault
Sep 25, 2017·Intensive Care Medicine·Hans FlaattenUNKNOWN VIP1 study group

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Citations

Jul 7, 2019·Zeitschrift für Gerontologie und Geriatrie·Guido MichelsHans Jürgen Heppner
Jul 7, 2019·Medizinische Klinik, Intensivmedizin und Notfallmedizin·Guido MichelsHans Jürgen Heppner
Mar 4, 2020·International Journal of Environmental Research and Public Health·Tan Van NguyenTu Ngoc Nguyen
May 10, 2020·Anesthesia and Analgesia·Justin C De BiasioShahzad Shaefi
May 18, 2020·Clinical Hemorheology and Microcirculation·Raphael Romano BrunoChristian Jung
May 31, 2019·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Carmel L MontgomerySean M Bagshaw
May 15, 2020·MMW Fortschritte der Medizin·Joachim ZeehAnja Kwetkat
Dec 9, 2020·The American Journal of Bioethics : AJOB·Dominic J C Wilkinson
Dec 29, 2020·Deutsches Ärzteblatt International·Christian JungMalte Kelm
Mar 2, 2021·European Geriatric Medicine·Sónia Bastos MoreiraJosé-Artur Paiva
May 1, 2021·Geriatrics·David G SmithardAngelo Pieris
Jul 1, 2021·BMC Geriatrics·Ioannis VrettosDimitris Niakas
Jul 9, 2021·International Journal of Clinical Oncology·Kosuke MimaHideo Baba

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NCT03134807

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