Clinical guidance for the use of trazodone in major depressive disorder and concomitant conditions: pharmacology and clinical practice

Rivista di psichiatria
Alessandro CuomoAndrea Fagiolini

Abstract

To provide a review of the clinically relevant evidence pertaining to the use of trazodone in major depressive disorder. Medline and Cochrane Library searches were searched using the keywords 'trazodone' AND 'depression', to identify the most relevant literature pertinent to the pharmacological properties of trazodone and its use in clinical practice. Articles that were selected included basic pharmacology papers, clinical trials, clinical practice guidelines, and reviews. Related references were cross checked. European and United States prescribing information was reviewed as well. An effort was made to give weight to the information that was most relevant for daily clinical practice. Trazodone is an antidepressant with a mechanism of action that remains innovative and with a favorable profile for the treatment of depression. The appropriate antidepressant doses are usually 150-300 mg/day and are often higher than the doses that are used when trazodone is prescribed to augment the antidepressant effect of another medication, for instance when trazodone is prescribed to address insomnia in a patient treated with an SSRI. Trazodone is usually well tolerated and has a low risk of anticholinergic side effects, weight gain and sexu...Continue Reading

Citations

Sep 29, 2021·European Journal of Clinical Pharmacology·Takezo TsutsumiYoh Takekuma
Oct 26, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Domenico De BerardisMassimo Di Giannantonio

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