Clinical, haematological and histomorphological profile of adult myelodysplastic syndrome. Study of 96 cases in a single institute

European Journal of Haematology
T ChatterjeeV P Choudhry

Abstract

Myelodysplastic syndromes (MDS) are clonal haematopoietic stem cell disorders characterised by ineffective and dyspoietic haematopoiesis. The natural history of these disorders is variable and ranges from a chronic to a rapid course towards leukaemic progression. Certain shortcomings have been encountered in the French-American-British (FAB) classification over the years, and therefore there is a need for an alternative method of classification. In 1999, the WHO published a revised classification of MDS. In the present study, we have analysed the clinical, haematological and histomorphological features in 96 cases of primary MDS seen in the department of haematology at the All India Institute of Medical Sciences (AIIMS) over a 6-yr period (1996-2001). Both FAB and WHO classifications have been incorporated and the Bournemouth scoring system applied in each case at presentation. The Bournemouth scoring system, in the absence of a cytogenetic study, offers a good prognostication and long-term survival estimate.

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Citations

May 12, 2005·Blood Reviews·Daniel V T Catenacci, Gary J Schiller
Aug 30, 2005·Leukemia Research·Semra Paydas
Jun 25, 2016·Oncotarget·Mi Young SonPaul Hasty
Jul 11, 2020·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Faran NaimJyoti Kotwal
Oct 18, 2008·Cancer Control : Journal of the Moffitt Cancer Center·Luca Malcovati, Stephen D Nimer
Apr 5, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Sadia SultanSyeda Narisa Jawed

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