Clinical, Hematologic, Biologic and Molecular Characteristics of Patients with Myeloproliferative Neoplasms and a Chronic Myelomonocytic Leukemia-Like Phenotype

Cancers
Sonja HeiblKlaus Geissler

Abstract

Patients with a myeloproliferative neoplasm (MPN) sometimes show a chronic myelomonocytic leukemia (CMML)-like phenotype but, according to the 2016 WHO classification, a documented history of an MPN excludes the diagnosis of CMML. Forty-one patients with an MPN (35 polycythemia vera (PV), 5 primary myelofibrosis, 1 essential thrombocythemia) and a CMML-like phenotype (MPN/CMML) were comprehensively characterized regarding clinical, hematologic, biologic and molecular features. The white blood cell counts in MPN/CMML patients were not different from CMML patients and PV patients. The hemoglobin values and platelet counts of these patients were higher than in CMML but lower than in PV, respectively. MPN/CMML patients showed myelomonocytic skewing, a typical in vitro feature of CMML but not of PV. The mutational landscape of MPN/CMML was not different from JAK2-mutated CMML. In two MPN/CMML patients, development of a CMML-like phenotype was associated with a decrease in the JAK2 V617F allelic burden. Finally, the prognosis of MPN/CMML (median overall survival (OS) 27 months) was more similar to CMML (JAK2-mutated, 28 months; JAK2-nonmutated 29 months) than to PV (186 months). In conclusion, we show that patients with MPN and a CMM...Continue Reading

References

Jan 1, 1988·Leukemia Research·K GeisslerK Lechner
Sep 20, 2002·Blood·James W VardimanRichard D Brunning
Sep 19, 2003·Wiener klinische Wochenschrift·Leopold OhlerWolfgang Hinterberger
Sep 29, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Leonardo BoiocchiAttilio Orazi
Jan 16, 2013·Blood·Raphaël ItzyksonEric Solary
Nov 21, 2013·Blood·Jiapeng WangFeng-Chun Yang
Feb 6, 2016·Blood Cancer Journal·M M Patnaik, A Tefferi
Nov 9, 2016·BMC Genomics·Christopher A MillerRichard K Wilson
Apr 4, 2017·American Journal of Hematology·Daniela BarracoAyalew Tefferi
Dec 22, 2017·British Journal of Haematology·Ayalew TefferiNaseema Gangat
Nov 22, 2016·Blood Advances·Ayalew TefferiAlessandro M Vannucchi
Jan 13, 2018·Blood Cancer Journal·Ayalew TefferiTiziano Barbui
Jun 8, 2018·American Journal of Hematology·Mrinal M Patnaik, Ayalew Tefferi
Apr 6, 2019·Leukemia Research Reports·Mirela AndreiJen Chin Wang

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Methods Mentioned

BETA
density gradient centrifugation
amplicon sequencing

Software Mentioned

SPSS

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