Clinical Heterogeneity of Interstitial Lung Disease in Polymyositis and Dermatomyositis Patients With or Without Specific Autoantibodies

The American Journal of the Medical Sciences
Fang ChenGuochun Wang

Abstract

The aim of this study was to compare the heterogeneity of interstitial lung disease (ILD) in patients with polymyositis and dermatomyositis (PM/DM) according to serological type. A total of 182 patients with PM/DM-ILD were observed retrospectively. Antiaminoacyl-tRNA synthetase (ARS) and antimelanoma differentiation-associated gene5 (MDA5) antibodies were screened using immunoblotting approach. The patients with ILD were divided into 3 groups: MDA5 (with anti-MDA5 antibody), ARS (with anti-ARS antibody) and MSN (without anti-MDA5 or anti-ARS antibody) group. Pulmonary features, treatment responses and prognoses were compared among the groups. A higher percentage of rapidly progressive ILD (RP-ILD) occurrences (55.8% versus 25% versus 16.9%, P < 0.001) was observed in the MDA5 group compared to ARS and MSN groups. The MSN group experienced lower dyspnea (48.2% versus 79% versus 71.4%, P = 0.001) and fever (18.1% versus 39.5% versus 37.5%, P = 0.01) frequencies compared to MDA5 and ARS groups. Response to 6-month treatment among 95 patients showed highest deterioration ratio (70%, P = 0.001) of ILD in the MDA5 group. Additionally, the highest frequency of ILD improvement (60%, P = 0.04) was observed in the ARS group. During the o...Continue Reading

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Citations

Jul 14, 2020·Current Opinion in Pulmonary Medicine·Toyoshi Yanagihara, Yoshikazu Inoue
Feb 16, 2019·Journal of Immunology Research·Charles CassiusReyhan Amode
Jan 28, 2020·Current Treatment Options in Rheumatology·Courtney ShappleyLesley Ann Saketkoo
Nov 20, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Hung-Ling HuangYuan-Ting Sun
Dec 4, 2019·Neuromuscular Disorders : NMD·Andrew L MammenUNKNOWN ENMC 239th Workshop Study Group
May 1, 2021·Medicina·Tomoyuki Fujisawa
May 11, 2021·Frontiers in Immunology·Andrea Aguilar-VazquezMonica Vazquez-Del Mercado

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