Clinical Imaging of Choroid Plexus in Health and in Brain Disorders: A Mini-Review

Frontiers in Molecular Neuroscience
Violaine HubertMarlène Wiart

Abstract

The choroid plexuses (ChPs) perform indispensable functions for the development, maintenance and functioning of the brain. Although they have gained considerable interest in the last years, their involvement in brain disorders is still largely unknown, notably because their deep location inside the brain hampers non-invasive investigations. Imaging tools have become instrumental to the diagnosis and pathophysiological study of neurological and neuropsychiatric diseases. This review summarizes the knowledge that has been gathered from the clinical imaging of ChPs in health and brain disorders not related to ChP pathologies. Results are discussed in the light of pre-clinical imaging studies. As seen in this review, to date, most clinical imaging studies of ChPs have used disease-free human subjects to demonstrate the value of different imaging biomarkers (ChP size, perfusion/permeability, glucose metabolism, inflammation), sometimes combined with the study of normal aging. Although very few studies have actually tested the value of ChP imaging biomarkers in patients with brain disorders, these pioneer studies identified ChP changes that are promising data for a better understanding and follow-up of diseases such as schizophrenia,...Continue Reading

References

Jul 1, 1992·Journal of Neurochemistry·C M MorrisR G Pullen
Feb 1, 1990·The American Journal of Physiology·M A MaktabiF M Faraci
Jul 1, 1993·The International Journal of Neuroscience·R Sandyk
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·V V RaoD Piwnica-Worms
Aug 5, 2000·Clinical Radiology·A GuermaziJ Frija
Nov 23, 2000·Neurology·R KiraT Hara
Sep 2, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Steven R Ennis, Richard F Keep
Nov 24, 2006·Stroke; a Journal of Cerebral Circulation·Marlène WiartYves Berthezène
Dec 16, 2006·Stroke; a Journal of Cerebral Circulation·Norbert NighoghossianMarc Hermier
Jul 12, 2008·Alcoholism, Clinical and Experimental Research·Peter F NixonFernando Zelaya
Aug 6, 2008·The Journal of Comparative Neurology·Silvia GazzinJean-François Ghersi-Egea
May 7, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Erica C HenningSteven Warach
Oct 24, 2009·Metabolic Brain Disease·Tracey A RouaultSuh Young Jeong
Mar 4, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ayush BatraErica C Henning
Oct 20, 2010·Journal of Neuroinflammation·Eva WuerfelJens T Wuerfel
Oct 29, 2010·International Journal of Clinical Pharmacology and Therapeutics·F ChauveauM Wiart
Mar 2, 2011·Brain, Behavior, and Immunity·Caroline DrakeStuart M Allan
Dec 6, 2011·Biochimica Et Biophysica Acta·Dominique F Leitner, James R Connor
Jan 13, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jussi HirvonenWilliam H Theodore
Feb 22, 2012·Journal of Alzheimer's Disease : JAD·Jean-Marie SerotPierre Jouanny
May 24, 2012·Surgical and Radiologic Anatomy : SRA·Megha MadhukarMark R Iantosca
Mar 19, 2013·Neuroscience·M ArtziD Ben Bashat
Jun 26, 2013·Neurobiology of Aging·Nelly Joseph-MathurinMarc Dhenain
Jul 24, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Eric A TanifumAnanth V Annapragada
Mar 25, 2015·NMR in Biomedicine·Matthew Grech-SollarsChris A Clark
Jun 13, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Ryogo MinamimotoAndrei Iagaru
Sep 22, 2015·Scientific Reports·Guangyu ZhouRiitta Hari
Nov 21, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Victoria López-RodríguezMiguel A Ávila-Rodríguez

❮ Previous
Next ❯

Citations

Dec 12, 2019·Journal of Neuroscience Research·Daniela TalhadaCecília Reis Alves Santos
Apr 17, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Wei Zheng, Jean-Francois Ghersi-Egea
May 1, 2020·Nature Communications·P G EvansJ A Wells
Dec 12, 2020·Brain Communications·Justine DebatisseEmmanuelle Canet-Soulas
May 4, 2021·Brain Communications·Vanessa Di CataldoEmmanuelle Canet-Soulas
Aug 17, 2021·Frontiers in Cell and Developmental Biology·Paola PerinRoberto Pizzala

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
imaging technique

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.