Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
M C FirmidaA J Lopes

Abstract

The rate of diagnosis of colonization/infection of the airways with Achromobacter xylosoxidans has increased in cystic fibrosis patients, but its clinical significance is still controversial. This retrospective, case-control study aimed to evaluate the clinical impact of A. xylosoxidans colonization/infection in cystic fibrosis patients. Individuals who were chronically colonized/infected (n=10), intermittently colonized/infected (n=15), and never colonized/infected with A. xylosoxidans (n=18) were retrospectively evaluated during two periods that were 2 years apart. Demographic characteristics, clinical data, lung function, and chronic bacterial co-colonization data were evaluated. Of the total study population, 87% were pediatric patients and 65.1% were female. Individuals chronically colonized/infected with A. xylosoxidans had decreased forced expiratory volume in 1 s (51.7% in the chronic colonization/infection group vs 82.7% in the intermittent colonization/infection group vs 76% in the never colonized/infected group). Compared with the other two groups, the rate of co-colonization with methicillin-resistant Staphylococcus aureus was higher in individuals chronically colonized/infected with A. xylosoxidans (P=0.002). Chang...Continue Reading

References

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Citations

Feb 1, 2017·Respiratory Medicine Case Reports·Mônica Cássia FirmidaAgnaldo José Lopes
Jun 14, 2017·Pediatric Pulmonology·Adrienne P Savant, Susanna A McColley
Aug 11, 2018·Current Opinion in Pulmonary Medicine·Heather Green, Andrew M Jones
Aug 7, 2021·Antibiotics·Viola Camilla ScoffoneSilvia Buroni

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