Clinical Impact of Antibiotics for the Treatment of Pseudomonas aeruginosa Biofilm Infections

Frontiers in Microbiology
Elodie OlivaresFrançois Jehl

Abstract

Bacterial biofilms are highly recalcitrant to antibiotic therapies due to multiple tolerance mechanisms. The involvement of Pseudomonas aeruginosa in a wide range of biofilm-related infections often leads to treatment failures. Indeed, few current antimicrobial molecules are still effective on tolerant sessile cells. In contrast, studies increasingly showed that conventional antibiotics can, at low concentrations, induce a phenotype change in bacteria and consequently, the biofilm formation. Understanding the clinical effects of antimicrobials on biofilm establishment is essential to avoid the use of inappropriate treatments in the case of biofilm infections. This article reviews the current knowledge about bacterial growth within a biofilm and the preventive or inducer impact of standard antimicrobials on its formation by P. aeruginosa. The effect of antibiotics used to treat biofilms of other bacterial species, as Staphylococcus aureus or Escherichia coli, was also briefly mentioned. Finally, it describes two in vitro devices which could potentially be used as antibiotic susceptibility testing for adherent bacteria.

Citations

Jan 1, 1978·Scientific American·J W CostertonK J Cheng
May 2, 1998·Science·D G DaviesEverett Peter Greenberg
Oct 29, 1998·Molecular Microbiology·George A O'Toole, R Kolter
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·I ValletA Filloux
Aug 22, 2001·Journal of Bacteriology·Morten HentzerM R Parsek
Oct 26, 2001·Nature·M WhiteleyEverett Peter Greenberg
Feb 23, 2002·Science·Cynthia B WhitchurchJohn S Mattick
Aug 28, 2002·International Journal of Medical Microbiology : IJMM·Philip S Stewart
Nov 25, 2003·Nature·Thien-Fah MahGeorge A O'Toole
Aug 18, 2004·Journal of Medical Microbiology·A P FonsecaJ C Sousa
Dec 8, 2004·Journal of Clinical Microbiology·Richard J Gillis, Barbara H Iglewski
Apr 6, 2005·Biochemistry. Biokhimii︠a︡·Kim Lewis
Aug 27, 2005·Nature·Lucas R HoffmanSamuel I Miller
Dec 27, 2005·Antimicrobial Agents and Chemotherapy·Raphael SaginurKaram Ramotar
Dec 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·J F LinaresJ L Martinez
Jan 16, 2007·Journal of Microbiological Methods·Patrick ChavantThierry Bernardi
May 13, 2008·Journal of Bacteriology·Li Zhang, Thien-Fah Mah
Jul 23, 2008·Antimicrobial Agents and Chemotherapy·Mette E SkindersoeMichael Givskov
Jul 16, 2009·Environmental Microbiology·Rustam I Aminov
Feb 13, 2010·International Journal of Antimicrobial Agents·Niels HøibyOana Ciofu
Jun 29, 2010·FEMS Immunology and Medical Microbiology·Peter Østrup JensenClaus Moser
Apr 13, 2011·International Journal of Oral Science·Niels HøibyThomas Bjarnsholt
Nov 15, 2011·The Journal of Infectious Diseases·Alexandro Rodríguez-RojasJesús Blázquez
Nov 19, 2011·The International Journal of Artificial Organs·Jeffrey B Kaplan
Nov 29, 2011·Nature Reviews. Microbiology·Diane McDougaldStaffan Kjelleberg
Sep 26, 2012·Medical Microbiology and Immunology·Chase WattersKendra P Rumbaugh
Oct 8, 2013·Microbial Ecology·Lawrence R MulcahyKim Lewis
Dec 7, 2013·Critical Reviews in Microbiology·Mira Okshevsky, Rikke Louise Meyer
Mar 25, 2014·Dose-response : a Publication of International Hormesis Society·Mandy NgJeffrey B Kaplan
Apr 29, 2014·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Hong-Jing HePei-Yuan Xia
May 13, 2014·Journal of Microbiological Methods·A E ParkerA Omar
Nov 12, 2014·Advances in Experimental Medicine and Biology·Brian P ConlonKim Lewis
Dec 3, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Yvonne C W YauValerie Waters

Related Concepts

Staphylococcus aureus
Pseudomonas aeruginosa
Microbial Biofilms
Biofilm Formation
Escherichia coli
Determination of Bacterial Growth
Antibiotic Therapy
Microbicides
Antibiotics
Study

Related Feeds

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.