Clinical Impact of Breast Cancer Stem Cells in Metastatic Breast Cancer Patients

Journal of Oncology
M A ElbaiomyS Shamaa

Abstract

Breast tumors are composed of phenotypically diverse groups of cells; however, it is unclear which of these cells contribute to tumor development. Breast cancer management usually targets proliferating cells, but as breast cancer stem cells are slowly cycling, they may escape these targets whenever they are not actively proliferating. This may explain the occurrence of recurrences and failure of the treatment. To assess the impact of the BCSC expression on progression-free survival (PFS), overall survival (OS), and tumor response in metastatic breast cancer patients and to correlate the BCSC expression with different clinicopathological parameters. This prospective study enrolled 76 de novo metastatic breast cancer patients recruited from the Oncology Center, Mansoura University, Egypt, with a minimum age 31 years and a maximum of 70 years. Pretreatment BCSC markers (CD44 and CD24) were assessed by immunohistochemistry on formalin-fixed paraffin-embedded tumor tissues from a primary or metastatic site. Patients received different lines of treatment, hormonal or chemotherapy, according to their biological subtypes. Anti-Her2 was added for Her2-positive patients. Thirty-three patients (43.4%) were premenopausal and 43 patients (5...Continue Reading

References

Nov 2, 2001·Nature·T ReyaI L Weissman
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
Sep 28, 2006·Annual Review of Medicine·Piero DalerbaMichael F Clarke
Dec 21, 2006·Journal of the National Cancer Institute·Tiffany M PhillipsFrank Pajonk
May 1, 2008·Journal of the National Cancer Institute·Xiaoxian LiJenny C Chang
Jun 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Madhuri Kakarala, Max S Wicha
Mar 12, 2009·Current Cancer Drug Targets·Philippe L BedardFatima Cardoso
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tomonori TaneiShinzaburo Noguchi
Dec 17, 2009·Human Pathology·Sebastian AulmannHans Peter Sinn
Dec 24, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emmanuelle Charafe-JauffretMax S Wicha
Jan 28, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·So Yeon ParkKornelia Polyak
May 28, 2010·Stem Cells·Gangadharan B SajithlalEdward V Prochownik
Sep 3, 2010·The Breast : Official Journal of the European Society of Mastology·Hee Jeong KimGyungyub Gong
Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Huiping LiuMichael F Clarke
Oct 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Xiaolong WeiPatricia K Donahoe
Jan 21, 2011·Nature·Jane E Visvader
Jun 17, 2011·Future Oncology·Marco A Velasco-VelázquezRichard G Pestell
Jul 28, 2011·OncoTargets and Therapy·Pham Van PhucPhan Kim Ngoc
Nov 29, 2011·Breast Cancer Research and Treatment·Mohamed A H AhmedIan O Ellis
Jan 18, 2012·The International Journal of Biochemistry & Cell Biology·Marco A Velasco-VelázquezRichard G Pestell
May 23, 2012·Clinical & Experimental Metastasis·Erhong MengRodney P Rocconi
Jul 6, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Rachel EyreAnnette P Meeson

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BETA
biopsy
xenografts

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SPSS ( Statistical System for Social Science )
Excel

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