Clinical impact of combined transarterial chemoembolization and radiotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis: An external validation study

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Jeong Il YuJong Hoon Kim

Abstract

To evaluate the relationship between portal vein tumor thrombosis (PVTT) response and clinical outcomes in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization followed by radiotherapy (TACE-RT). The study enrolled 329 patients in the training set and 179 patients in the validation set. All patients who were treated with TACE-RT from 2002 to 2008 and satisfied the inclusion criteria were enrolled in the study. The median follow-up period was 11.7 months (range, 1.6-108.6) in the training set and 11.9 months (range, 1.7-105.1) in the validation set. After TACE-RT, PVTT response was complete or partial in 32 (9.7%) and 134 (40.7%) patients of the training set and in 18 (10.1%) and 96 (53.6%) patients in the validation set, respectively. Failure to obtain PVTT response was significantly related with elevated post-treatment Child-Pugh score (P<0.001). Furthermore, progression-free survival was significantly related with PVTT response (P<0.001, hazard ratio 0.33, 95% confidence interval 0.25-0.42) in multivariate analysis. In receiver-operating characteristics analysis of 1-year progression prediction, the PVTT response showed an area under the curve of 0.74. Most of the findings were successfull...Continue Reading

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Citations

May 13, 2017·Clinical and Molecular Hepatology·Hyo-Cheol Kim
Feb 13, 2018·Journal of Radiation Research·Diego A S ToescaDaniel T Chang
Mar 28, 2018·Radiation Oncology Journal·Jeong Il YuHee Chul Park
Sep 21, 2017·Abdominal Radiology·Scott M ThompsonSudhakar K Venkatesh
May 7, 2019·Gut and Liver·UNKNOWN Korean Liver Cancer Association, UNKNOWN National Cancer Center
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Jun 7, 2019·World Journal of Gastroenterology : WJG·Changhoon ChoiHee Chul Park
Aug 30, 2016·World Journal of Gastroenterology : WJG·Jeong Il Yu, Hee Chul Park
Aug 8, 2019·The Lancet. Gastroenterology & Hepatology·Jian LuGao-Jun Teng
Jun 26, 2021·International Journal of Radiation Oncology, Biology, Physics·Cheng-Hsiang LoWen-Yen Huang

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