Clinical Impact of Consolidative and Salvage Radiotherapy for Lymph Node Metastasis in Upper Urinary Tract Urothelial Carcinoma

Case Reports in Urology
Hideyuki KondoMasafumi Oyama

Abstract

A 75-year-old Japanese male was referred to our institution for the evaluation of a left ureteral tumor in the ureterovesical junction. Computed tomography and pathologic examination under ureteroscopy revealed an invasive left ureteral urothelial carcinoma with left obturator nodal metastasis without distant metastasis. First, the patient underwent systemic chemotherapy (gemcitabine and cisplatin chemotherapy). We then performed left radical nephroureterectomy and extended lymph node dissection. Pathological examination revealed that the tumor was a high-grade invasive urothelial carcinoma with left common iliac and pelvic lymph node metastasis (pT3N2). Unfortunately, metastases appeared in the common iliac and para-aortic lymph nodes immediately after the operation; therefore, the previous first-line chemotherapy was readministered and second-line chemotherapy (gemcitabine and paclitaxel chemotherapy) was also performed. We also performed consolidative radiotherapy and salvage radiotherapy (boost, 20 Gy/10 fractions to the inferior para-aortic, and left common iliac regions containing swollen lymph nodes). The patient has shown no evidence of recurrence or metastasis even approximately 4 years after the initial diagnosis of a...Continue Reading

References

Jul 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans von der MaaseMichael Arning
Jan 22, 2009·Cancer·Vitaly MargulisUNKNOWN Upper Tract Urothelial Carcinoma CollaborationThe Upper Tract Urothelial Carcinoma Collaboration
Feb 13, 2009·Japanese Journal of Clinical Oncology·Takahito SuyamaMasayuki Maruoka
Apr 21, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Tsunenori Kondo, Kazunari Tanabe
Jun 23, 2015·The Journal of Urology·Surena F MatinPhilippe E Spiess

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Citations

Jan 27, 2019·Molecular and Clinical Oncology·Suguru ShirotakeKoshiro Nishimoto
Nov 16, 2018·Frontiers in Neurology·Young-Kook KimJuhyun Song

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Methods Mentioned

BETA
biopsy
dissection

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