Clinical impact of endoscopic ultrasound-guided through-the-needle microbiopsy in patients with pancreatic cysts.

Endoscopy
Bojan KovacevicPeter Vilmann

Abstract

The limited data on the utility of endoscopic ultrasound (EUS)-guided through-the-needle biopsies (TTNBs) in patients with pancreatic cystic lesions (PCLs) originate mainly from retrospective studies. Our aim was to determine the clinical impact of TTNBs, their added diagnostic value, and the adverse event rate in a prospective setting. This was a prospective, single-center, open-label controlled study. Between February 2018 and August 2019, consecutive patients presenting with a PCL of 15 mm or more and referred for EUS were included. Primary outcome was a change in clinical management of PCLs following TTNB compared with cross-sectional imaging and cytology. Adverse events were defined according to the ASGE lexicon. 101 patients were included. TTNBs led to a change in clinical management in 11.9 % of cases (n = 12). Of these, 10 had serous cysts and surveillance was discontinued, while one of the remaining two cases underwent surgery following diagnosis of a mucinous cystic neoplasm. The diagnostic yield of TTNBs for a specific cyst diagnosis was higher compared with FNA cytology (69.3 % vs. 20.8 %, respectively; P < 0.001). The adverse event rate was 9.9 % (n = 10; 95 % confidence interval 5.4 % - 17.3 %), with the most comm...Continue Reading

References

May 17, 2008·The British Journal of Mathematical and Statistical Psychology·Kilem Li Gwet
Mar 2, 2010·Gastrointestinal Endoscopy·Peter B CottonJohn J Vargo
Apr 1, 2010·The American Journal of Gastroenterology·Karen S LeeIvan Pedrosa
Feb 12, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·G D ThorntonK J Monahan
Feb 21, 2016·Gastroenterology Clinics of North America·Gyanprakash A KetwarooMandeep S Sawhney
Jul 25, 2017·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Masao TanakaChristopher L Wolfgang
Mar 7, 2018·Gastrointestinal Endoscopy·Omer BasarWilliam R Brugge
Apr 17, 2018·Cancer Cytopathology·M Lisa ZhangMartha B Pitman
May 29, 2018·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Luca BarresiAlberto Larghi
Nov 25, 2018·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Dennis YangPeter V Draganov
Jul 7, 2019·Histopathology·Charlotte Vestrup RiftJane Preuss Hasselby
Nov 7, 2019·Histopathology·Charlotte Vestrup RiftJane Preuss Hasselby

❮ Previous
Next ❯

Citations

Aug 25, 2020·Digestive Diseases and Sciences·María-Victoria Alvarez-Sánchez, Bertrand Napoléon
Dec 18, 2020·Endoscopy·Bojan KovacevicPeter Vilmann
Jul 23, 2021·Der Pathologe·Lena HäberleIrene Esposito
Aug 13, 2021·Digestive Diseases and Sciences·Andrew Canakis, Linda S Lee
Jun 21, 2021·Gastrointestinal Endoscopy·Tiffany Y ChuaJenifer R Lightdale

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.