Clinical Impact of Highly Purified, Whey Proteins in Patients Affected With Colorectal Cancer Undergoing Chemotherapy: Preliminary Results of a Placebo-Controlled Study

Integrative Cancer Therapies
Federica MazzucaPaolo Marchetti

Abstract

Background and Aims: Sarcopenia, the loss of both lean body and skeletal muscle mass, may interfere in cancer patients outcome. As investigated, whey proteins could prevent the onset of sarcopenia. We have conducted a study to evaluate the effects of whey protein in colorectal cancer patients, undergoing 5-fluorouracil-based chemotherapy. Methods: After written informed consent, patients were blind randomized 1:1 to whey protein (ProLYOtin; arm A) versus placebo (arm B). The patients were assessed both physically and nutritionally before chemotherapy and after 3 (T2) and 6 months (T3) by body impedance assessment, L3-computed tomography scan, Mini Nutritional Assessment (MNA), and Malnutrition Universal Screening Tool (MUST) tests. Results: Forty-seven patients were included in this preliminary analysis. Baseline characteristics were well balanced between the 2 arms. During chemotherapy, 33 patients were reevaluated: anthropometric parameters (lean body mass from 68.5% to 71.2% vs 68.7% to 66.3%, and sarcopenia from 84% to 54% and 83% to 77% from baseline to T2 evaluation in arms A and B, respectively), nutritional status (MNA >24 = 100% [A] vs 73.7% [B]), and toxicity (no adverse effects in 86% [A] vs 29% [B] and 94% [A] vs 29...Continue Reading

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Citations

Apr 30, 2020·Journal of the National Cancer Institute·Jennifer L GuidaKirsten K Ness
Sep 23, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Senem KarabulutDidem Tastekin
Apr 10, 2020·Current Osteoporosis Reports·Nicole KissRobin M Daly
Oct 24, 2020·Australasian Journal on Ageing·Ben KirkGustavo Duque
May 28, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Grant R WilliamsBette J Caan

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Software Mentioned

ProLYOtin
MUST
MNA
SPSS
MetaDieta
Slice
- Matic

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