Abstract
Background and Aims: Sarcopenia, the loss of both lean body and skeletal muscle mass, may interfere in cancer patients outcome. As investigated, whey proteins could prevent the onset of sarcopenia. We have conducted a study to evaluate the effects of whey protein in colorectal cancer patients, undergoing 5-fluorouracil-based chemotherapy. Methods: After written informed consent, patients were blind randomized 1:1 to whey protein (ProLYOtin; arm A) versus placebo (arm B). The patients were assessed both physically and nutritionally before chemotherapy and after 3 (T2) and 6 months (T3) by body impedance assessment, L3-computed tomography scan, Mini Nutritional Assessment (MNA), and Malnutrition Universal Screening Tool (MUST) tests. Results: Forty-seven patients were included in this preliminary analysis. Baseline characteristics were well balanced between the 2 arms. During chemotherapy, 33 patients were reevaluated: anthropometric parameters (lean body mass from 68.5% to 71.2% vs 68.7% to 66.3%, and sarcopenia from 84% to 54% and 83% to 77% from baseline to T2 evaluation in arms A and B, respectively), nutritional status (MNA >24 = 100% [A] vs 73.7% [B]), and toxicity (no adverse effects in 86% [A] vs 29% [B] and 94% [A] vs 29...Continue Reading
References
Feb 13, 2001·European Journal of Clinical Investigation·P MickeR Buhl
Oct 10, 2001·International Journal of Sport Nutrition and Exercise Metabolism·D G BurkeT Smith-Palmer
Jun 5, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carla M M PradoMichael B Sawyer
Jan 29, 2008·Experimental Biology and Medicine·Jonathan LeblondMoïse Coëffier
Mar 29, 2008·Nutrition & Metabolism·Joy L FrestedtEric D Bastian
Apr 9, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carla M M PradoMichael B Sawyer
Feb 26, 2010·The Journal of Nutrition·Nabile BoukhettalaMoïse Coëffier
Jan 17, 2012·The British Journal of Surgery·M G van VledderJ N M Ijzermans
Jul 16, 2015·The Oncologist·Oscar ArrietaVickie E Baracos
Feb 18, 2016·Journal of Food Science and Technology·Seema Patel
Aug 22, 2017·International Journal of Medical Sciences·Wen-Ching HuangSheng-Shih Chen
Oct 5, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Davis A EnglundRoger A Fielding
Nov 8, 2017·Oncotarget·Maurizio MuscaritoliUNKNOWN PreMiO Study Group
Feb 23, 2018·Journal of Evidence-based Integrative Medicine·Joseph Gbenga OmoleBenson Akinloye Fadeyi
Mar 23, 2018·Journal of Medicinal Food·Akkarach BumrungpertAraya Adulbhan
Oct 20, 2018·BMC Cancer·Paolo CotogniAntonella De Francesco
Citations
Apr 30, 2020·Journal of the National Cancer Institute·Jennifer L GuidaKirsten K Ness
Sep 23, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Senem KarabulutDidem Tastekin
Jun 27, 2020·BMC Cancer·G TorbahnD Volkert
Apr 10, 2020·Current Osteoporosis Reports·Nicole KissRobin M Daly
Oct 24, 2020·Australasian Journal on Ageing·Ben KirkGustavo Duque
May 28, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Grant R WilliamsBette J Caan