Clinical impact of intraoperative histological examination of the ductal resection margin in extrahepatic cholangiocarcinoma

The British Journal of Surgery
M KonishiA Yanagisawa

Abstract

Although ductal resection margin status in extrahepatic cholangiocarcinoma is evaluated by intraoperative histological examination of frozen sections, its clinical relevance remains controversial. Material taken from patients who underwent R0 or R1 resection for extrahepatic cholangiocarcinoma with intraoperative histological examination of the final ductal resection margins between 1994 and 2003 were reviewed. The following histological classification was used: insufficient, negative for malignancy (NM), undetermined lesion (UDL) or positive for malignancy (PM). Multivariable analyses of overall survival and anastomotic recurrence in relation to ductal margin status were performed. Resection material from 363 patients was identified. For the proximal ductal margin, only PM in intramural lesions was significantly associated with poor survival (hazard ratio (HR) 1.72, 95 per cent confidence interval (c.i.) 1.06 to 2.74) and anastomotic recurrence (HR 6.39, 95 per cent c.i. 1.89 to 21.62) compared with NM. In analysis of overall survival according to distal ductal margin status, the HRs for UDL and PM lesions in comparison with NM were not significant. PM in intramural lesions found during intraoperative histological examination ...Continue Reading

References

Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J KlempnauerR Pichlmayr
Jan 1, 2000·Annals of Surgery·P NeuhausR Hintze
Sep 27, 2001·Annals of Surgery·W R JarnaginL H Blumgart
Nov 19, 2004·Journal of Hepato-biliary-pancreatic Surgery·Gerd OttoFernando Bittinger
Dec 29, 2004·Annals of Surgery·Jin-Young JangYong-Hyun Park
Apr 26, 2005·Annals of Surgery·Alan W HemmingRichard J Howard
Jan 27, 2007·Journal of the American College of Surgeons·Olivier BatonDenis Castaing
Nov 27, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E HidalgoJ P A Lodge
Jun 11, 2008·Annals of Surgical Oncology·Itaru EndoWilliam R Jarnagin
Oct 7, 2008·Journal of Hepato-biliary-pancreatic Surgery·Marcus BahraPeter Neuhaus
Feb 13, 2009·Annals of Surgery·Tsuyoshi IgamiYoshie Shimoyama

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Citations

Oct 23, 2015·Expert Review of Gastroenterology & Hepatology·Yasuni NakanumaTsuneyuki Uchida
Apr 1, 2014·The Surgical Clinics of North America·Paxton V Dickson, Stephen W Behrman
Mar 20, 2015·Journal of Hepato-biliary-pancreatic Sciences·Masaru MiyazakiTadahiro Takada
Dec 20, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J LeeS-W Kim
Sep 10, 2018·Journal of Surgical Oncology·Siyuan YaoShinji Uemoto
Nov 9, 2011·Journal of the Korean Surgical Society·Sun Choon SongMin Jung Kim
Nov 17, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Tae YooEun Kyung Hong
Sep 22, 2018·Annals of Gastroenterological Surgery·Toshifumi WakaiTakashi Kobayashi
May 8, 2018·Annals of Surgical Treatment and Research·Naru KimHyeon Kook Lee
Jul 30, 2020·Annals of Gastroenterological Surgery·Teiichi SugiuraAkira Fukutomi

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