Clinical Impact of Muscle Quantity and Quality in Colorectal Cancer Patients: A Propensity Score Matching Analysis

JPEN. Journal of Parenteral and Enteral Nutrition
Yoshinaga OkugawaMasato Kusunoki

Abstract

Sarcopenia is defined as the loss of skeletal muscle mass, accompanied by decreased muscle strength, and consists of myopenia and myosteatosis. Recent evidence has suggested the predictive value of sarcopenia for the risk of perioperative and oncological outcomes in various malignancies. The aim of this study was to clarify the clinical impact of myopenia and myosteatosis in colorectal cancer (CRC) patients. We analyzed the preoperative psoas muscle mass index and intramuscular adipose tissue content using preoperative computed tomography images from 308 CRC patients using statistical methods. Despite no significant correlation between myosteatosis and prognosis, preoperative myopenia significantly correlated with clinicopathological factors for disease development, including advanced tumor depth (P = 0.009), presence of lymphatic vessel invasion (P = 0.006), distant metastasis (P = 0.0007), and advanced stage classification (P = 0.013). Presence of preoperative myopenia was an independent prognostic factor for both cancer-specific survival (hazard ratio [HR]: 2.75, 95% confidence interval [CI]: 1.5-5.05, P = 0.001) and disease-free survival (HR: 3.15, 95% CI: 1.8-5.51, P = 0.0001), and was an independent risk factor for postop...Continue Reading

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Citations

May 3, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Lijun HouChao Sun
Jul 10, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K KusunokiM Kusunoki
Jan 24, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mayra Cruz-FernándezIrene Cantarero-Villanueva
May 16, 2019·Journal of Cachexia, Sarcopenia and Muscle·Yoshinaga OkugawaMasato Kusunoki
Apr 12, 2020·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Yu-San TeeChi-Hsun Hsieh
Jun 3, 2020·Journal of Cachexia, Sarcopenia and Muscle·Chan Mi Lee, Jeonghyun Kang
May 3, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Yukina KusunokiMasato Kusunoki
Oct 14, 2021·Cancer Medicine·In Kyu ParkJeonghyun Kang

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