Clinical impact of rapid susceptibility testing on MHR-SIR directly from blood cultures

The Journal of Antimicrobial Chemotherapy
Benoît PilmisJean-Claude Nguyen Van

Abstract

In a previous study, we demonstrated that rapid antibiotic susceptibility tests (ASTs) can be performed directly on blood culture samples tested on Mueller-Hinton Rapid agar (MHR-SIR) with a time delay of 6-8 h. Using this rapid disc diffusion method, we analysed the clinical impact associated with rapid reporting of results in our hospital setting. All patients with bloodstream infections (BSIs) related to Enterobacteriaceae or Staphylococcus aureus were prospectively included in the study. The rapid ASTs were performed by incubation of positive blood cultures on MHR-SIR for 6-8 h by direct inoculation according to BSAC recommendations. One hundred and sixty-seven patients with BSIs were included as MHR-guided adaptation therapy cases. Eighty percent had Enterobacteriaceae-related BSIs, of which 12 (9%) were ESBL producers and 20% were S. aureus-related BSIs. A urinary or intra-abdominal infection was observed in 44.3% and 19.8%, respectively, of Enterobacteriaceae-related infections. The most frequent sources of infections for S. aureus BSIs were cutaneous and endovascular, in 43% and 23% of cases, respectively. Forty-four percent of the patients benefited from therapeutic modification according to the results of the MHR-SIR ...Continue Reading

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Citations

Mar 1, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Jasmin Kaur JasujaIrene Burckhardt
Feb 25, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Benoît PilmisJean-Claude Nguyen Van
Jan 20, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Ying Tong SooKa Lip Chew
May 22, 2020·Journal of Clinical Microbiology·Catherine Anne HoganNiaz Banaei
Jun 8, 2021·The Cochrane Database of Systematic Reviews·Vanesa Anton-VazquezTimothy Planche

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