Clinical Impact of the Cell-of-Origin Classification and the MYC/ BCL2 Dual Expresser Status in Diffuse Large B-Cell Lymphoma Treated Within Prospective Clinical Trials of the German High-Grade Non-Hodgkin's Lymphoma Study Group

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Annette M StaigerGerman High-Grade Lymphoma Study Group

Abstract

Purpose To explore the prognostic impact and interdependence of the cell-of-origin (COO) classification, dual expression (DE) of MYC and BCL2 proteins, and MYC, BCL2, and BCL6 translocations in two prospectively randomized clinical trials of patients with diffuse large B-cell lymphoma (DLBCL). Patients and Methods Overall, 452 formalin-fixed paraffin-embedded samples from two prospective, randomized DLBCL trials (RICOVER-60, prospective, randomized study for patients > 60 years, all IPI groups; and R-MegaCHOEP, prospective, randomized study for patients ≤ 60 years with age-adjusted IPI 2,3) of the German High-Grade Non-Hodgkin Lymphoma Study Group were analyzed with the Lymph2Cx assay for COO classification, with immunohistochemistry for MYC and BCL2, and with fluorescent in situ hybridization for MYC, BCL2, and BCL6 rearrangements. Results COO classification was successful in 414 of 452 samples. No significant differences with respect to COO (activated B-cell [ABC]-like DLBCL v germinal center B-cell [GCB]-like DLBCL) were observed in event-free survival, progression-free survival, and overall survival in patients treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in the RICOVER-60 ...Continue Reading

References

Jun 21, 2002·The New England Journal of Medicine·Andreas RosenwaldUNKNOWN Lymphoma/Leukemia Molecular Profiling Project
Aug 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·George WrightLouis M Staudt
Jan 30, 2008·The Lancet Oncology·Michael PfreundschuhUNKNOWN German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL)
Feb 19, 2008·Nature Biotechnology·Gary K GeissKrassen Dimitrov
Sep 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Georg LenzLouis M Staudt
Nov 29, 2008·The New England Journal of Medicine·G LenzUNKNOWN Lymphoma/Leukemia Molecular Profiling Project
May 19, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Heidi NymanSirpa Leppä
Aug 27, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·William W L ChoiWing C Chan
Apr 14, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marita ZiepertMarkus Loeffler
Nov 3, 2010·The Journal of Clinical Investigation·Leandro C CerchiettiAri Melnick
Dec 8, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul N MeyerDennis D Weisenburger
Mar 29, 2011·Blood·Gonzalo Gutiérrez-GarcíaUNKNOWN Grup per l'Estudi dels Limfomes de Catalunya I Balears (GELCAB)
Sep 6, 2011·Cell·Jake E DelmoreConstantine S Mitsiades
Jun 6, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tina Marie GreenMichael Boe Møller
Aug 2, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nathalie A JohnsonRandy D Gascoyne
Sep 12, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anas YounesJoy Zhu
Nov 28, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David W ScottRandy D Gascoyne
Jan 22, 2013·Blood·Heike HornUNKNOWN German High-Grade Non-Hodgkin Lymphoma Study Group
Jul 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Matthias PfeiferGeorg Lenz
Nov 13, 2013·Nature Reviews. Clinical Oncology·Mark RoschewskiWyndham H Wilson
Oct 17, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kieron DunleavyWyndham H Wilson
Jul 21, 2015·Nature Medicine·Wyndham H WilsonLouis M Staudt
Aug 5, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David W ScottRandy D Gascoyne

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Citations

Apr 25, 2018·British Journal of Haematology·Adam J OlszewskiJohn L Reagan
Jul 6, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Qian ShiChristopher R Flowers
Jul 11, 2018·Expert Review of Hematology·Shaoying LiL Jeffrey Medeiros
Oct 17, 2018·Leukemia & Lymphoma·Maria Joao BaptistaJosé-Tomas Navarro
Mar 13, 2019·American Journal of Hematology·Yang Liu, Stefan Klaus Barta
Dec 7, 2018·Hematology·Allison Rosenthal, Lisa Rimsza
May 24, 2019·Expert Review of Hematology·Lin-Rong LiKen H Young
Sep 10, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andreas RosenwaldDelphine Maucort-Boulch
May 19, 2020·American Society of Clinical Oncology Educational Book·Jeremy S AbramsonSonali M Smith
May 14, 2020·International Journal of Cancer. Journal International Du Cancer·Shiyu JiangYuankai Shi
Aug 20, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer L Crombie, Philippe Armand
Jun 23, 2018·Current Treatment Options in Oncology·Thomas A Ollila, Adam J Olszewski
Dec 13, 2018·Journal of Translational Medicine·Joseph A ImpellizeriLuigi Aurisicchio
Dec 14, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wing C Chan
Jul 6, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Siba El HusseinFrancisco Vega
May 8, 2018·Virchows Archiv : an International Journal of Pathology·Sarah ReinkeWolfram Klapper
May 29, 2018·Virchows Archiv : an International Journal of Pathology·Jing ZhangZhiyong Liang
Jan 3, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Erik A Ranheim
Aug 14, 2019·British Journal of Haematology·Kevin MellertPeter Möller

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