Clinical impact of thrombus aspiration during primary percutaneous coronary intervention: results from Korea Acute Myocardial Infarction Registry

Journal of cardiology
Daisuke HachinoheKorea Acute Myocardial Infarction Registry Investigators

Abstract

The role of thrombus aspiration (TA) as an adjunct to primary percutaneous coronary intervention (PPCI) remains a matter of controversy. A total of 2105 patients enrolled in the nationwide prospective Korea Acute Myocardial Infarction Registry, a cohort of 745 (35.4%) patients who underwent TA during PPCI was compared with 1360 (64.6%) patients who underwent conventional PCI without TA. Clinical outcomes at 12-months of overall enrolled patients and subgroups according to key variables were assessed using Cox regression models adjusted by propensity score. Although there was no significant difference among overall patients, in subgroup analyses, administration of glycoprotein (GP) IIb/IIIa inhibitor during PPCI [adjusted hazard ratio (HR) 0.329, 95% confidence interval (CI) 0.126-0.860, p=0.023] and left anterior descending (LAD) as a culprit lesion (adjusted HR 0.516, 95% CI 0.275-0.971, p=0.040) were the settings, in which TA was associated with a lower major adverse cardiac events (MACE) rate compared with non-TA. Although TA does not improve clinical outcomes in overall patients who underwent PPCI, TA for LAD occlusion improves 12-month MACE. Furthermore, use of GP IIb/IIIa inhibitor with TA has a synergistic effect on clin...Continue Reading

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Citations

Feb 13, 2016·Journal of cardiology·Doo Sun SimUNKNOWN other Korea Acute Myocardial Infarction Registry (KAMIR) Investigators
Oct 17, 2017·Korean Circulation Journal·Doo Sun Sim, Myung Ho Jeong
May 29, 2014·Circulation. Cardiovascular Interventions·Diego Fernández-RodríguezUNKNOWN EXAMINATION investigators
Oct 19, 2017·Circulation. Cardiovascular Interventions·Junhua GePeter Nordbeck
Nov 8, 2014·The Korean Journal of Internal Medicine·Hyun Kuk KimYoung Jo Kim
Feb 6, 2020·Chonnam Medical Journal·Seok-Woo SeongUNKNOWN Korea Acute Myocardial Infarction Registry-National Institute of Health investigators
Apr 7, 2021·Korean Circulation Journal·Kiyuk ChangUNKNOWN Task Force on Expert Consensus Document of the Korean Society of Myocardial Infarction (KSMI)

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