Clinical implication of expression of vascular endothelial growth factor-C in metastatic lymph nodes of uterine cervical cancers

British Journal of Cancer
Jiro FujimotoTeruhiko Tamaya

Abstract

Vascular endothelial cell growth factor (VEGF)-C levels were significantly (P<0.05) increased in 24 out of 40 metastatic lymph node lesions of uterine cervical cancers. The prognosis of the 24 patients with increased VEGF-C level in metastatic lymph node lesions was poor and the 24-month survival rate was 38%, while the rate of the 16 patients with no change in VEGF-C level in metastatic lymph node lesions was 81%. There was a significant (P<0.01) difference in the 24-month survival rates between the two groups. This is novel, direct evidence that VEGF-C might contribute to the aggressive lymphangitic metastasis in uterine cervical cancers, and that the increase in VEGF-C level from primary tumour to metastatic lymph node might be a prognostic indicator.

References

Apr 15, 1986·Cancer·P E SaigoJ L Lewis
Jun 1, 1987·Gynecologic Oncology·H NoguchiT Fukuta
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·J LeeW I Wood
May 30, 1997·Science·M JeltschK Alitalo
Jun 13, 1998·Gynecologic Oncology·R J ChenC Y Hsieh
Apr 12, 2002·International Journal of Cancer. Journal International Du Cancer·Mirjami M-T MattilaPirkko L Härkönen
Jul 2, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T AmiokaK Chayama

❮ Previous
Next ❯

Citations

Jun 15, 2007·Acta Oncologica·Pia P VihinenSeppo O Pyrhönen
Nov 17, 2015·Expert Review of Anticancer Therapy·Gulden MenderesAlessandro D Santin
Feb 25, 2006·Journal of Biotechnology·Wilko Thiele, Jonathan P Sleeman
Apr 30, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Jiro FujimotoTeruhiko Tamaya
May 17, 2007·British Journal of Cancer·E SatoT Tamaya
Oct 3, 2006·Journal of Biomedical Science·Jiro FujimotoTeruhiko Tamaya
Mar 30, 2006·British Journal of Cancer·A V TimoshenkoP K Lala
Apr 19, 2019·ESMO Open·Chakor Vora, Sudeep Gupta
Mar 1, 2011·Hormone Molecular Biology and Clinical Investigation·Jiro Fujimoto, Eriko Sato
Mar 17, 2020·Frontiers in Oncology·Yolla HaibeAli Shamseddine
Mar 17, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Syeda Kiran RiazMuhammad Faraz Arshad Malik
May 15, 2021·Human Vaccines & Immunotherapeutics·Sylvia Annabel DassVenugopal Balakrishnan
Mar 9, 2007·Blood Cells, Molecules & Diseases·Zaher K OtrockAli I Shamseddine

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
hysterectomy
ELISA

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.