Clinical implication of F-18 FDG PET/CT for differentiated thyroid cancer in patients with negative diagnostic iodine-123 scan and elevated thyroglobulin

European Journal of Radiology
Seong-Jang KimYong-Ki Kim

Abstract

This study aims to investigate the usefulness of F-18 FDG PET/CT in differentiated thyroid cancer (DTC) with elevated serum thyroglobulin (Tg) but negative iodine-123 (I-123) scan. Twenty patients with histopathologically proven DTC, negative diagnostic I-123 scan, and elevated serum Tg levels were prospectively submitted to F-18 FDG PET/CT evaluation. The histopathologic findings consisted of 19 papillary thyroid cancers, 1 follicular thyroid cancer. F-18 FDG PET/CT identified lesions in 18 out of 20 patients, giving a sensitivity of 90%. Thirteen of the 18 patients revealed limited loco-regional disease. Remaining 5 patients showed distant metastases, consisting of 4 patients with lung metastases and 1 patient with bone metastasis. Two patients revealed negative F-18 FDG PET/CT findings. F-18 FDG PET/CT is suitable for the detection and precise localization of loco-regional recurrences and distant metastases of DTC in patients with elevated serum Tg but negative I-123 whole body scan.

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Citations

Jun 27, 2013·Annals of Nuclear Medicine·Shanmuga Sundaram Palaniswamy, Padma Subramanyam
Feb 24, 2011·ANZ Journal of Surgery·Ivan Ho ShonPeter Campbell
Jan 29, 2011·Seminars in Nuclear Medicine·Tony Abraham, Heiko Schöder
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Nov 5, 2016·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Johann-Martin HempelMatthias Miederer
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Jan 1, 2012·Expert Review of Endocrinology & Metabolism·Luca Giovanella
Jul 12, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Masatoyo NakajoTakashi Yoshiura

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