Clinical Implication of MicroRNAs in Molecular Pathology: An Update for 2018

Clinics in Laboratory Medicine
S SethiMartin H Bluth

Abstract

MicroRNAs (miRNAs) are poised to provide diagnostic, prognostic, and therapeutic targets for several diseases including malignancies for precision medicine applications. The miRNAs have immense potential in the clinical arena because they can be detected in the blood, serum, tissues (fresh and formalin-fixed paraffin-embedded), and fine-needle aspirate specimens. The most attractive feature of miRNA-based therapy is that a single miRNA could be useful for targeting multiple genes that are deregulated in cancers, which can be further investigated through systems biology and network analysis that may provide cancer-specific personalized therapy.

Citations

Aug 22, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chao YangLikun Zhuang
Dec 5, 2019·Expert Review of Molecular Diagnostics·Antonio Lopez-BeltranRodolfo Montironi
Feb 29, 2020·Technology in Cancer Research & Treatment·Fuquan JiangLinlin Wang
Oct 4, 2019·Oncology Letters·Yinghao Lv, Shuai Huang
Sep 25, 2018·Frontiers in Oncology·Giorgio SantoniNicola Battelli
Feb 10, 2021·International Journal of Molecular Sciences·Elif Damla ArisanPinar Uysal-Onganer

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