Clinical implication of natural killer cells and reproduction

American Journal of Reproductive Immunology : AJRI
Joanne Kwak-Kim, A Gilman-Sachs

Abstract

The regulation of natural killer (NK) cells in the peripheral blood and endometrial layers has been associated with reproductive immunopathology such as recurrent spontaneous abortions (RSA), infertility of implantation failures, or pre-eclampsia. The placenta has a complex anatomical structure and different subsets of NK cells with various functional roles can directly interact with trophoblasts. NK cell subpopulations and their functions, putative roles of NK cells in peripheral blood and endometrium are reviewed in relation to RSA and infertility. An increase in NK cell numbers and /or activity in pre- or post-conceptional period in women with RSA or infertility with multiple implantation failures are a significant clinical concern. In addition, immuno-phenotypic characteristics of NK cells in these women support the changes for their increased activity status. Further studies are needed to explore underlying mechanism of NK cells in RSA, infertility, and other reproductive immunopathologies. Possible neurological and hormonal control of NK cells and NK cell interaction with various leukocyte populations need further investigation in women with reproductive failures.

References

Jan 1, 1995·American Journal of Reproductive Immunology : AJRI·C B CoulamK D Beaman
Jul 1, 1995·American Journal of Obstetrics and Gynecology·J A HillP M Johnson
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·S BahramT Spies
Apr 1, 1997·European Journal of Immunology·S VermaY W Loke
Jun 16, 1997·The Journal of Experimental Medicine·E CarboneS Zappacosta
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·N Rouas-FreissE D Carosella
Mar 18, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·R ChiarleG Inghirami
Mar 31, 1999·American Journal of Reproductive Immunology : AJRI·A Gilman-SachsK D Beaman
Jul 7, 1999·American Journal of Reproductive Immunology : AJRI·A FukuiY Saito
Nov 8, 2001·Trends in Immunology·M A CooperM A Caligiuri
Nov 20, 2001·American Journal of Reproductive Immunology : AJRI·H MatsubayashiT Makino
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sirirak ChantakruB Anne Croy
Jun 19, 2002·American Journal of Reproductive Immunology : AJRI·Udo R MarkertBettina A Mock
Jun 19, 2002·American Journal of Reproductive Immunology : AJRI·Toshihiko MichimataSigeru Saito
Jul 11, 2002·Journal of Reproductive Immunology·Sulani S SouzaJulio C Voltarelli
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Margaret A HolmesRoland K Strong
Aug 31, 2004·Human Reproduction·C S WittF T Christiansen

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Citations

Nov 17, 2009·Clinical Reviews in Allergy & Immunology·Elena Peeva
Oct 2, 2013·Journal of Human Reproductive Sciences·Pratap Kumar, Siddharth Mahajan
Nov 29, 2013·Human Reproduction Update·Srividya Seshadri, Sesh Kamal Sunkara
Nov 13, 2009·Clinical Reviews in Allergy & Immunology·Caterina De CarolisRoberto Perricone
Sep 17, 2009·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·D Cudihy, R V Lee
Nov 21, 2015·American Journal of Reproductive Immunology : AJRI·Chengdong ZhangXiaoli Yang
Dec 24, 2011·Autoimmunity Reviews·Grant C Hughes
Jun 7, 2011·Fertility and Sterility·Alek M ItseksonHoward J A Carp
Jul 8, 2011·Journal de gynécologie, obstétrique et biologie de la reproduction·G DucarmeD Luton
Nov 6, 2010·Reproductive Biomedicine Online·Eva MikoLaszlo Szereday
Nov 10, 2009·Journal of Reproductive Immunology·Anshula Alok, Anjali A Karande
Sep 10, 2010·American Journal of Reproductive Immunology : AJRI·Hyunkyong AhnJoanne Kwak-Kim
Feb 22, 2012·American Journal of Reproductive Immunology : AJRI·Carolyn B Coulam, Brian Acacio
Aug 18, 2010·American Journal of Reproductive Immunology : AJRI·Gerasimos PerrosMarighoula Varla-Leftherioti
Mar 14, 2013·American Journal of Reproductive Immunology : AJRI·Rocío Ramos-MedinaSilvia Sánchez-Ramón
May 8, 2013·American Journal of Reproductive Immunology : AJRI·Gisela JunovichGabriela Gutierrez
Jun 22, 2010·American Journal of Reproductive Immunology : AJRI·Bettina TothUdo Jeschke
Mar 20, 2010·American Journal of Reproductive Immunology : AJRI·Viktor P ChernyshovYulia V Masliy
Nov 17, 2009·American Journal of Reproductive Immunology : AJRI·Ageliki PantaziMarighoula Varla-Leftherioti
May 20, 2015·Journal of Reproductive Immunology·Faezeh Naderi-MahabadiFarah Idali
Jan 31, 2015·Biochemical and Biophysical Research Communications·Feng JiangYuanqing Yao
Dec 3, 2014·Immunology Letters·Viktor P ChernyshovYana O Goncharova
May 18, 2016·Journal of Integrative Medicine·Boris V Dons'koiSergiy M Baksheev
Apr 26, 2017·American Journal of Reproductive Immunology : AJRI·Louise KofodThomas Vauvert F Hviid
Jan 31, 2017·Journal of Dairy Science·Scott J DenholmEileen Wall
Aug 5, 2017·American Journal of Reproductive Immunology : AJRI·Michael L DaviesKenneth D Beaman
Jan 4, 2019·American Journal of Reproductive Immunology : AJRI·Longfei LiYong Zeng
Dec 18, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·L TrogstadC Stoltenberg
Aug 1, 2019·Molecular Genetics & Genomic Medicine·Meysam Moghbeli
Jul 25, 2019·American Journal of Reproductive Immunology : AJRI·Daria BortolottiRoberta Rizzo
Mar 13, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yun Jung HurYou Shin Kim
Sep 24, 2014·Journal of Leukocyte Biology·Tatyana Lysakova-Devine, Cliona O'Farrelly
Apr 22, 2019·American Journal of Reproductive Immunology : AJRI·Youssef DerbalaJoanne Kwak-Kim
Mar 9, 2019·Journal of Assisted Reproduction and Genetics·Kevin Marron, Conor Harrity

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