Clinical implication of serum WFA+ -M2BP level on Hepatitis B e Antigen loss or Seroconversion in Hepatitis B e Antigen-positive patients

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Hiroki NishikawaShuhei Nishiguchi

Abstract

To examine the impact of pretreatment Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA(+) -M2BP) level on hepatitis B e antigen (HBeAg) loss or HBeAg seroconversion (SC) for patients with nucleoside analogue (NUC) therapy naïve HBeAg-positive chronic hepatitis B (CHB). A total of 57 were analysed. All subjects were initially treated with NUCs. We examined the impact of pretreatment WFA(+) -M2BP level on HBeAg loss and HBeAg SC using univariate and multivariate analyses. There were 36 males and 21 females (median age, 39 years). The WFA(+) -M2BP level ranged from 0.43 cutoff index (COI) to 12.9 COI (median value, 1.55 COI). WFA(+) -M2BP level in patients with F3 or 4 (n = 18) was significantly higher than that with F0-2 (n = 39) (P < 0.01). WFA(+) -M2BP level in patients with A2 or 3 (n = 31) was significantly higher than that with A0 or 1 (n = 26) (P < 0.001). For all cases, the 1- and 3-year cumulative HBeAg loss rates were 10.5% and 34.4% and the corresponding cumulative HBeAg SC rates were 8.8% and 29.0%. In the multivariate analysis, in terms of HBeAg loss, pretreatment HBV-DNA ≥5 log copies/ml (P = 0.0675) and pretreatment WFA(+) -M2BP level >1.55 COI (P = 0.0973) tended to be significant factors linked t...Continue Reading

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